Journal article
Increased biological oxidation and reduced anti-oxidant enzyme activity in pre-eclamptic placentae
Placenta , Vol.26(1), pp.53-58
2005
PMID: 15664411
Abstract
Oxidative stress occurs when cellular levels of reactive oxygen species exceed anti-oxidant capabilities and has been implicated in the pathogenesis of pre-eclampsia. In this study we have examined the tissue levels of endogenous anti-oxidant proteins (superoxide dismutase, glutathione peroxidase, thioredoxin reductase and thioredoxin) and the level of lipid and protein oxidation in placental samples from normal and pre-eclamptic pregnancies. Pre-eclamptic tissue homogenates demonstrated significantly increased levels of lipid peroxidation ( protein versus protein, P<0.001) and a trended increase in protein carbonyl concentration ( protein versus protein) when compared to controls. The levels and activities of the anti-oxidant proteins superoxide dismutase ( protein versus protein, P<0.02), thioredoxin reductase ( protein versus protein, P=0.02), thioredoxin ( protein versus protein, P=0.02) and glutathione peroxidase ( protein versus , P<0.02) were all found to be significantly reduced when comparing pre-eclamptic placental tissue homogenates to gestational age-matched control placentae from non-pre-eclamptic pregnancies. The results of this study demonstrate a decreased enzymatic anti-oxidant capacity and increased oxidation in placental tissue from pre-eclamptic women, which may contribute to the pathogenesis of this complex disorder.
Details
- Title
- Increased biological oxidation and reduced anti-oxidant enzyme activity in pre-eclamptic placentae
- Authors
- J. Vanderlelie (Author) - Griffith UniversityK. Venardos (Author) - Griffith UniversityV.L. Clifton (Author) - Hunter Medical Research InstituteN.M. Gude (Author) - Royal Women's HospitalF.M. Clarke (Author) - Griffith UniversityA.V. Perkins (Corresponding Author) - Griffith University
- Publication details
- Placenta , Vol.26(1), pp.53-58
- Publisher
- Elsevier Ltd.
- DOI
- 10.1016/j.placenta.2004.04.002
- ISSN
- 1532-3102
- PMID
- 15664411
- Organisation Unit
- School of Health and Behavioural Sciences - Legacy; School of Health
- Language
- English
- Record Identifier
- 99685195102621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Developmental Biology
- Obstetrics & Gynecology
- Reproductive Biology
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Source: InCites