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In vivo imaging of oxidative stress and fronto-limbic white matter integrity in young adults with mood disorders
Journal article   Peer reviewed

In vivo imaging of oxidative stress and fronto-limbic white matter integrity in young adults with mood disorders

Daniel F Hermens, Sean N Hatton, Rico S C Lee, Sharon L Naismith, Shantel L Duffy, G Paul Amminger, Manreena Kaur, Elizabeth M Scott, Jim Lagopoulos and Ian B Hickie
European Archives of Psychiatry and Clinical Neuroscience, Vol.268(2), pp.145-156
2018
DOI: https://doi.org/10.1007/s00406-017-0788-8
Appears in  Thompson Institute Research Collection
url
https://doi.org/10.1007/s00406-017-0788-8View
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Abstract

diffusion tensor imaging hippocampus depression bipolar disorder magnetic resonance spectroscopy glutathione Other Collaborations Thompson Institute Special Collection UniSC Diversity Area - Disability and Inclusion UniSC Diversity Area - Life Stages
Fronto-limbic connectivity is compromised in mood disorders, as reflected by impairments in white matter (WM) integrity revealed by diffusion tensor imaging. Although the underlying mechanisms remain unclear, disruption to normal myelination due to oxidative stress is thought to play a key role. We aimed to determine whether fronto-limbic WM integrity is compromised, and associated with in vivo antioxidant levels (indexed by glutathione; GSH), in young adults with unipolar depression (DEP) and bipolar (BD) disorders. Ninety-four patients with DEP, 76 with BD and 59 healthy controls (18-30 years) underwent diffusion tensor and proton magnetic resonance spectroscopy imaging. Fractional anisotropy (FA) was calculated from the cingulum bundle (cingulate, hippocampus), fornix, stria terminalis (ST) and uncinate fasciculus tracts. GSH concentration was measured in anterior cingulate cortex (ACC) and hippocampus (HIPP). Compared to controls, DEP showed significantly reduced FA in ST, whereas BD did not significantly differ in FA across the five tracts. There were significant positive correlations between ST-FA and HIPP-GSH across groups. Regression analysis revealed that having DEP or BD and reduced HIPP-GSH were significantly associated with reduced ST-FA. Similarly, decreased ST-FA was associated with poorer neuropsychological performance in conjunction with having DEP. Our findings suggest a structural disconnectivity specific to the limbic region of young adults with DEP. Decreased WM integrity was associated with depleted levels of hippocampal GSH suggesting that this particular disruption may be linked to oxidative stress at early stages of illness. Young adults with BD do not have the same degree of impairment.

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