In vivo glutathione levels in young persons with bipolar disorder: A magnetic resonance spectroscopy study

Jim Lagopoulos; Daniel F Hermens; J Tobias-Webb; S Duffy; S L Naismith; D White; E Scott; I B Hickie

doi:10.1016/j.jpsychires.2012.12.006

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In vivo glutathione levels in young persons with bipolar disorder: A magnetic resonance spectroscopy study

Journal article

Peer reviewed

In vivo glutathione levels in young persons with bipolar disorder: A magnetic resonance spectroscopy study

Jim Lagopoulos, Daniel F Hermens, J Tobias-Webb, S Duffy, S L Naismith, D White, E Scott and I B Hickie

Journal of Psychiatric Research, Vol.47(3), pp.412-417

2013

DOI: https://doi.org/10.1016/j.jpsychires.2012.12.006

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Abstract

glutathione

spectroscopy

bipolar disorder

N-acetyl cysteine

Oxidative stress has recently been reported to assume a significant role in the pathophysiology of bipolar disorder. Several studies have demonstrated the replenishment of glutathione (GSH) diminishes oxidative cellular damage and ameliorates depressive symptoms in this disorder. Whilst the mechanism by which GSH exerts any clinical effect is unknown it has been proposed that it involves the bolstering of antioxidant defences by increasing the bioavailability of GSH, which in turn reverses clinical symptoms of depression. Such a proposal is predicated on the implicit assumption that GSH is diminished in these patients prior to GSH supplementation. However hitherto no study has reported in vivo measures of GSH in patients with bipolar disorder. Using magnetic resonance spectroscopy we obtained in vivo measures of GSH in young people with bipolar disorder and contrasted these with matched healthy controls. Young people with bipolar disorder were found to have no diminution in baseline GSH concentration and, furthermore, no significant correlations were found between GSH and clinical scores of depression or mania. The results do not support the hypothesis that oxidative stress is involved in the primary pathophysiology of bipolar disorder. © 2012 Elsevier Ltd.

Details

Title: In vivo glutathione levels in young persons with bipolar disorder: A magnetic resonance spectroscopy study
Authors: Jim Lagopoulos (Author) - University of Sydney
Daniel F Hermens (Author) - University of Sydney
J Tobias-Webb (Author) - University of Sydney
S Duffy (Author) - University of Sydney
S L Naismith (Author) - University of Sydney
D White (Author) - University of Sydney
E Scott (Author) - University of Sydney
I B Hickie (Author) - University of Sydney
Publication details: Journal of Psychiatric Research, Vol.47(3), pp.412-417
Publisher: Pergamon
Date published: 2013
DOI: 10.1016/j.jpsychires.2012.12.006
ISSN: 0022-3956
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99449598102621
Output Type: Journal article

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