In vivo evidence for early neurodevelopmental anomaly of the anterior cingulate cortex in bipolar disorder

A Fornito; G S Malhi; Jim Lagopoulos; B Ivanovski; S J Wood; D Velakoulis; M M Saling; P D McGorry; C Pantelis; M Yücel

doi:10.1111/j.1600-0447.2007.01069.x

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In vivo evidence for early neurodevelopmental anomaly of the anterior cingulate cortex in bipolar disorder

Journal article

Peer reviewed

In vivo evidence for early neurodevelopmental anomaly of the anterior cingulate cortex in bipolar disorder

A Fornito, G S Malhi, Jim Lagopoulos, B Ivanovski, S J Wood, D Velakoulis, M M Saling, P D McGorry, C Pantelis and M Yücel

Acta Psychiatrica Scandinavica, Vol.116(6), pp.467-472

2007

DOI: https://doi.org/10.1111/j.1600-0447.2007.01069.x

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Abstract

affective

mania

prefrontal cortex

magnetic resonance imaging

Objective: Anterior cingulate cortex (ACC) abnormalities are commonly reported in studies of patients with bipolar disorder (BD), but it is unclear whether these precede or follow illness onset. We investigated the evidence for early neurodevelopmental anomalies in the ACC and adjacent paracingulate cortex (PaC) of BD patients by studying cortical folding patterns of the region. Method: Magnetic resonance images were acquired from 54 BD patients and 116 healthy controls. Cortical folding patterns were assessed by classifying the incidence of the paracingulate sulcus (PCS) and interruptions in the course of the cingulate sulcus (CS). Results: Patients were significantly less likely to show a PCS bilaterally. There were no differences in the frequency of CS interruptions. Conclusion: The bilateral reduction observed in our patient sample implicates aberrant pre- or peri-natal developmental processes. To our knowledge, this is the first in vivo evidence for early neurodevelopmental anomaly of the ACC/PaC region in BD. © 2007 The Authors.

Details

Title: In vivo evidence for early neurodevelopmental anomaly of the anterior cingulate cortex in bipolar disorder
Authors: A Fornito (Author) - University of Melbourne
G S Malhi (Author) - University of Sydney
Jim Lagopoulos (Author) - University of Sydney
B Ivanovski (Author) - University of Melbourne
S J Wood (Author) - University of Melbourne
D Velakoulis (Author) - University of Melbourne
M M Saling (Author) - University of Melbourne
P D McGorry (Author) - ORGYGEN Research Centre
C Pantelis (Author) - University of Melbourne
M Yücel (Author) - University of Melbourne
Publication details: Acta Psychiatrica Scandinavica, Vol.116(6), pp.467-472
Publisher: Wiley-Blackwell Publishing Inc.
Date published: 2007
DOI: 10.1111/j.1600-0447.2007.01069.x
ISSN: 0001-690X
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99449549902621
Output Type: Journal article

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