In vitro susceptibility of recent Chlamydia trachomatis clinical isolates to the CtHtrA inhibitor JO146

Vanissa A Ong; Amba Lawrence; Peter Timms; Lenka A Vodstrcil; Sepehr N Tabrizi; Kenneth W Beagley; John A Allan; Jane S Hocking; Wilhelmina M Huston

doi:10.1016/j.micinf.2015.09.004

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In vitro susceptibility of recent Chlamydia trachomatis clinical isolates to the CtHtrA inhibitor JO146

Journal article

Open access

Peer reviewed

In vitro susceptibility of recent Chlamydia trachomatis clinical isolates to the CtHtrA inhibitor JO146

Vanissa A Ong, Amba Lawrence, Peter Timms, Lenka A Vodstrcil, Sepehr N Tabrizi, Kenneth W Beagley, John A Allan, Jane S Hocking and Wilhelmina M Huston

Microbes and Infection, Vol.17(11/12), pp.738-744

2015

DOI: https://doi.org/10.1016/j.micinf.2015.09.004

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Abstract

chlamydia

clinical isolate

HtrA

inhibitor

The present study aimed to establish if a previously identified Chlamydia trachomatis HtrA (CtHtrA) inhibitor, JO146, is effective against currently circulating clinical isolates to validate if CtHtrA is a clinically relevant target for future therapeutic development. Inhibition of CtHtrA during the middle of the chlamydial replicative cycle until the completion of the cycle resulted in loss of infectious progeny for six unique clinical isolates representing different serovars. This supports the potential for CtHtrA to be a clinically relevant target for development of new therapeutics and suggests the importance of further investigation of JO146 as a lead compound.

Details

Title: In vitro susceptibility of recent Chlamydia trachomatis clinical isolates to the CtHtrA inhibitor JO146
Authors: Vanissa A Ong (Author) - Queensland University of Technology
Amba Lawrence (Author) - Queensland University of Technology
Peter Timms (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Lenka A Vodstrcil (Author) - University of Melbourne
Sepehr N Tabrizi (Author) - University of Melbourne
Kenneth W Beagley (Author) - Queensland University of Technology
John A Allan (Author) - Wesley Hospital
Jane S Hocking (Author) - University of Melbourne
Wilhelmina M Huston (Author) - Queensland University of Technology
Publication details: Microbes and Infection, Vol.17(11/12), pp.738-744
Publisher: Elsevier Masson
Date published: 2015
DOI: 10.1016/j.micinf.2015.09.004
ISSN: 1286-4579
Organisation Unit: University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99449371902621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Immunology; Infectious Diseases; Microbiology

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Source: InCites