In Vitro Efficacy of Moxidectin versus Ivermectin against Sarcoptes scabiei

Kate E Mounsey; Shelley F Walton; Ashlee Innes; Skye Cash-Deans; James S McCarthy

doi:10.1128/AAC.00381-17

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In Vitro Efficacy of Moxidectin versus Ivermectin against Sarcoptes scabiei

Journal article

Peer reviewed

In Vitro Efficacy of Moxidectin versus Ivermectin against Sarcoptes scabiei

Kate E Mounsey, Shelley F Walton, Ashlee Innes, Skye Cash-Deans and James S McCarthy

Antimicrobial Agents and Chemotherapy, Vol.61(8), e00381-17

2017

DOI: https://doi.org/10.1128/AAC.00381-17

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Abstract

ivermectin

moxidectin

Sarcoptes scabiei

scabies

treatment

Moxidectin is under consideration for development as a treatment for human scabies. As some arthropods show decreased sensitivity to moxidectin relative to ivermectin, it was important to assess this for Sarcoptes scabiei. In-vitro assays showed that the concentration of moxidectin required to kill 50% of mites was lower compared to ivermectin (0.5 μM vs 1.8 μM at 24 hours, p <0.0001). This finding provides further support for moxidectin as a candidate for the treatment of human scabies.

Details

Title: In Vitro Efficacy of Moxidectin versus Ivermectin against Sarcoptes scabiei
Authors: Kate E Mounsey (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Shelley F Walton (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Ashlee Innes (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Skye Cash-Deans (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
James S McCarthy (Author) - University of Queensland
Publication details: Antimicrobial Agents and Chemotherapy, Vol.61(8), e00381-17; 5
Publisher: American Society for Microbiology
Date published: 2017
DOI: 10.1128/AAC.00381-17
ISSN: 0066-4804
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health - Anatomy; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99450684702621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Microbiology; Pharmacology & Pharmacy

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