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Impulsivity-related cognition in alcohol dependence - Is it moderated by DRD2 - ANKK1 gene status and executive dysfunctio413.42 kB
Accepted VersionCC BY-NC-ND V4.0, Open Access
Journal article
Impulsivity-related cognition in alcohol dependence: Is it moderated by DRD2/ANKK1 gene status and executive dysfunction?
Addictive Behaviors, Vol.39(11), pp.1663-1669
2014
PMID: 24629326
Abstract
Perceived impaired control over alcohol use is a key cognitive construct in alcohol dependence that has been related prospectively to treatment outcome and may mediate the risk for problem drinking conveyed by impulsivity in non-dependent drinkers. The aim of the current study was to investigate whether perceived impaired control may mediate the association between impulsivity-related measures (derived from the Short-form Eysenck Personality Questionnaire—Revised) and alcohol-dependence severity in alcohol-dependent drinkers. Furthermore, the extent to which this hypothesized relationship was moderated by genetic risk (Taq1A polymorphism in the DRD2/ANKK1 gene cluster) and verbal fluency as an indicator of executive cognitive ability (Controlled Oral Word Association Test) was also examined. A sample of 143 alcohol-dependent inpatients provided an extensive clinical history of their alcohol use, gave 10ml of blood for DNA analysis, and completed self-report measures relating to impulsivity, impaired control and severity of dependence. As hypothesized, perceived impaired control (partially) mediated the association between impulsivity-related measures and alcohol-dependence severity. This relationship was not moderated by the DRD2/ANKK1 polymorphism or verbal fluency. These results suggest that, in alcohol dependence, perceived impaired control is a cognitive mediator of impulsivity-related constructs that may be unaffected by DRD2/ANKK1 and neurocognitive processes underlying the retrieval of verbal information.
Details
- Title
- Impulsivity-related cognition in alcohol dependence: Is it moderated by DRD2/ANKK1 gene status and executive dysfunction?
- Authors
- Matthew J Gullo (Author) - The University of QueenslandNathan St. John (Author) - The University of QueenslandRoss Young (Author) - The University of QueenslandJohn B Saunders (Author) - The University of QueenslandErnest P Noble (Author) - University of California Los AngelesJason P Connor (Author) - The University of Queensland
- Publication details
- Addictive Behaviors, Vol.39(11), pp.1663-1669
- Publisher
- Elsevier Ltd
- Date published
- 2014
- DOI
- 10.1016/j.addbeh.2014.02.004
- ISSN
- 1873-6327; 0306-4603
- PMID
- 24629326
- Copyright note
- Copyright © 2014. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99550995002621
- Output Type
- Journal article
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- Psychology, Clinical
- Substance Abuse
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