Journal article
Improving human health through understanding the complex structure of glucose polymers
Analytical and Bioanalytical Chemistry, Vol.405(28), pp.8969-8980
2013
PMID: 23842899
Abstract
Two highly branched glucose polymers with similar structures-starch and glycogen-have important relations to human health. Slowly digestible and resistant starches have desirable health benefits, including the prevention and alleviation of metabolic diseases and prevention of colon cancer. Glycogen is important in regulating the use of glucose in the body, and diabetic subjects have an anomaly in their glycogen structure compared with that in healthy subjects. This paper reviews the biosynthesis-structure-property relations of these polymers, showing that polymer characterization produces knowledge which can be useful in producing healthier foods and new drug targets aimed at improving glucose storage in diabetic patients. Examples include mathematical modeling to design starch with better nutritional values, the effects of amylose fine structures on starch digestibility, the structure of slowly digested starch collected from in vitro and in vivo digestion, and the mechanism of the formation of glycogen alpha particles from beta particles in healthy subjects. A new method to overcome a current problem in the structural characterization of these polymers using field-flow fractionation is also given, through a technique to calibrate evaporative light scattering detection with starch.
Details
- Title
- Improving human health through understanding the complex structure of glucose polymers
- Authors
- Robert G. Gilbert (Corresponding Author) - Huazhong University of Science and TechnologyAlex C. Wu - Huazhong University of Science and TechnologyMitchell A Sullivan - Huazhong University of Science and TechnologyGonzalo E. Sumarriva - University of QueenslandNatascha Ersch - University of QueenslandJovin Hasjim - University of Queensland
- Publication details
- Analytical and Bioanalytical Chemistry, Vol.405(28), pp.8969-8980
- Publisher
- Springer
- Date published
- 2013
- DOI
- 10.1007/s00216-013-7129-1
- ISSN
- 1618-2650
- PMID
- 23842899
- Organisation Unit
- School of Health - Biomedicine
- Language
- English
- Record Identifier
- 991035098502621
- Output Type
- Journal article
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- International collaboration
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- Biochemical Research Methods
- Chemistry, Analytical
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