Journal article
Importance of human papillomavirus infection in squamous cell carcinomas of the tongue in Guangdong Province, China
Journal of International Medical Research, Vol.48(1)
2020
Abstract
Objective: Tongue squamous cell carcinoma is one of the most common oral tumors. Human papillomavirus (HPV) infection has been proposed as a risk factor for head and neck squamous cell carcinoma, particularly oropharyngeal squamous carcinoma. Methods: In this study, we retrospectively analyzed HPV infection in 121 Chinese patients with tongue squamous cell carcinoma in Guangdong Province. Polymerase chain reaction of HPV DNA and immunohistochemistry staining of p16 protein were used to identify the presence of HPV in formalin-fixed paraffin-embedded samples. Results: HPV DNA was detected in 15.7% (n= 19) of tongue squamous cell carcinoma patients, with HPV16 being the most common type (n= 8, 42.1%). p16 staining did not correlate with detection of HPV DNA. Male sex was associated with HPV-positive tongue squamous cell carcinoma, whereas there were no significant differences in alcohol consumption, smoking, or age when tumors were stratified by HPV. Conclusion: Our study showed that HPV infection contributed to tongue squamous cell carcinoma in a small cohort of patients in Guangdong Province, China. Further investigation is needed to confirm whether HPV is a causal factor for tongue squamous cell carcinoma.
Details
- Title
- Importance of human papillomavirus infection in squamous cell carcinomas of the tongue in Guangdong Province, China
- Authors
- Kunsong Huang (Author) - Guangdong Pharmaceutical University, ChinaGuoying Ni (Author) - University of the Sunshine CoastBowei Ma (Author) - Guangdong Pharmaceutical University, ChinaShu Chen (Author) - Forshan First People's Hospital, ChinaYi Luan (Author) - Forshan First People's Hospital, ChinaTianfang Wang (Author) - University of the Sunshine CoastShelley F Walton (Author) - University of the Sunshine CoastIan Fraser (Author) - University of QueenslandXiao Song Liu (Author) - University of the Sunshine CoastXuan Pan (Author) - Guangdong Pharmaceutical University, China
- Publication details
- Journal of International Medical Research, Vol.48(1); 13
- Publisher
- Sage Publications Ltd.
- Date published
- 2020
- DOI
- 10.1177/0300060519897187
- ISSN
- 0300-0605
- Copyright note
- Copyright © 2020. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99451319502621
- Output Type
- Journal article
Metrics
15 File views/ downloads
87 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Medicine, Research & Experimental
- Pharmacology & Pharmacy
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites