Impact of obesity and epicardial fat on early left atrial dysfunction assessed by cardiac MRI strain analysis

M Evin; Kathryn Broadhouse; F M Callaghan; R T McGrath; S Glastras; R Kozor; S L Hocking; J Lamy; A Redheuil; N Kachenoura; G R Fulcher; G A Figtree; S M Grieve

doi:10.1186/s12933-016-0481-7

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Impact of obesity and epicardial fat on early left atrial dysfunction assessed by cardiac MRI strain analysis

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Impact of obesity and epicardial fat on early left atrial dysfunction assessed by cardiac MRI strain analysis

M Evin, Kathryn Broadhouse, F M Callaghan, R T McGrath, S Glastras, R Kozor, S L Hocking, J Lamy, A Redheuil, N Kachenoura, …

Cardiovascular Diabetology, Vol.15(1), 164

2016

DOI: https://doi.org/10.1186/s12933-016-0481-7

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Abstract

diastolic dysfunction

cardiac dysfunction

magnetic resonance studies

fat distribution

obesity and type 2

Background: Diastolic dysfunction is a major cause of morbidity in obese individuals. We aimed to assess the ability of magnetic resonance imaging (MRI) derived left atrial (LA) strain to detect early diastolic dysfunction in individuals with obesity and type 2 diabetes, and to explore the association between cardiac adipose tissue and LA function. Methods: Twenty patients with obesity and T2D (55±8 years) and nineteen healthy controls (48±13 years) were imaged using cine steady state free precession and 2-point Dixon cardiovascular magnetic resonance. LA function was quantified using a feature tracking technique with definition of phasic longitudinal strain and strain rates, as well as radial motion fraction and radial velocities. Results: Systolic left ventricular size and function were similar between the obesity and type 2 diabetes and control groups by MRI. All patients except four had normal diastolic assessment by echocardiography. In contrast, measures of LA function using magnetic resonance feature tracking were uniformly altered in the obesity and type 2 diabetes group only. Although there was no significant difference in intra-myocardial fat fraction, Dixon 3D epicardial fat volume(EFV) was significantly elevated in the obesity and type 2 diabetes versus control group (135±31 vs. 90±30 mL/m2, p < 0.001). There were significant correlations between LA functional indices and both BMI and EFV (p ≤ 0.007). Conclusions: LA MRI-strain may be a sensitive tool for the detection of early diastolic dysfunction in individuals with obesity and type 2 diabetes and correlated with BMI and epicardial fat supporting a possible association between adiposity and LA strain. Trials Registration Australian New Zealand Clinical Trials Registry No. ACTRN12613001069741

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Title: Impact of obesity and epicardial fat on early left atrial dysfunction assessed by cardiac MRI strain analysis
Authors: M Evin (Author) - University of Sydney
Kathryn Broadhouse (Author) - University of Sydney
F M Callaghan (Author) - University of Sydney
R T McGrath (Author) - University of Sydney
S Glastras (Author) - University of Sydney
R Kozor (Author) - University of Sydney
S L Hocking (Author) - Royal North Shore Hospital
J Lamy (Author) - Institute of Cardiometabolism and Nutrition, France
A Redheuil (Author) - ICAN Institute of Cardiometabolism and Nutrition, France
N Kachenoura (Author) - ICAN Institute of Cardiometabolism and Nutrition, France
G R Fulcher (Author) - University of Sydney
G A Figtree (Author) - University of Sydney
S M Grieve (Author) - University of Sydney
Publication details: Cardiovascular Diabetology, Vol.15(1), 164; 10
Publisher: BioMed Central Ltd.
Date published: 2016
DOI: 10.1186/s12933-016-0481-7
ISSN: 1475-2840; 1475-2840
Copyright note: Copyright © The Author(s) 2016. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Organisation Unit: School of Science and Engineering - Legacy; School of Health - Nursing; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
Language: English
Record Identifier: 99451385502621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Cardiac & Cardiovascular Systems; Endocrinology & Metabolism

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