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Published VersionCC BY-NC-ND V4.0, Open Access
Journal article
Impact of genetic and genomic factors on host traits in striped catfish infected with Edwardsiella ictaluri
Aquaculture Science and Management, Vol.2, pp.1-13
2025
Abstract
Infectious diseases pose a significant threat to sustainable agricultural production. While conventional quantitative genetic theory has successfully enhanced the resistance of animal individuals or populations, it fails to consider epidemiological factors. As a result, it may not adequately capture the maximum genetic gains in selected populations. This study aims to address this limitation by employing a genetic-epidemiological model that enables the estimation of genetic parameters for three host traits: susceptibility, infectivity, and recovery (or removal/mortality). We conducted our analysis on a population of striped catfish (Pangasianodon hypophthalmus) exposed to the Edwardsiella ictaluri pathogen, which causes bacillary necrosis of pangasius (BNP) disease, through challenge test experiments using injection and cohabitation methods. A total of 560 individuals (490 offspring and 70 parents) were evaluated for disease resistance, measured as the time (in days) from the challenge test to death. Our analysis using the genetic-epidemiological model revealed significant heritability in the epidemiological host traits. The genetic variances for infectivity were found to be greater than those for susceptibility and mortality. Additionally, genetic correlations of susceptibility with infectivity and mortality were moderate and negative, while those between infectivity and mortality were positive. Significant SNPs obtained from our genome-wide scan exhibited small additive genetic and non-significant (or incomplete) dominant effects, suggesting polygenic nature of epidemiological host traits. Genomic prediction accuracies for the transition time between susceptibility and infectivity, as well between infectivity and mortality were moderate to high (0.16 – 0.73). These findings suggest promising prospects for improving epidemiological host traits in genetic programs to enhance the overall resilience of the striped catfish population. The selection index approach yielded a predicted genetic gain ranging from 5.5 – 10.3% per generation for the epidemiological host traits. The accuracy of the selection index was moderate (0.585). Our study provides fundamental genetic parameters for modelling alternative selection strategies aimed at increasing disease resilience to infectious diseases in striped catfish and other aquaculture species.
Details
- Title
- Impact of genetic and genomic factors on host traits in striped catfish infected with Edwardsiella ictaluri
- Authors
- Nguyen Hong Nguyen (Corresponding Author) - University of the Sunshine Coast, Queensland, Centre for BioinnovationNguyen Thanh Vu - James Cook UniversityThi Mai Huong Tran - University of the Sunshine Coast, Queensland, Centre for BioinnovationTran Huu Phuc - Research Institute for Aquaculture No. 2 (Vietnam)
- Publication details
- Aquaculture Science and Management, Vol.2, pp.1-13
- Publisher
- BioMed Central Ltd.
- Date published
- 2025
- DOI
- 10.1186/s44365-025-00006-6
- ISSN
- 3005-0723
- Copyright note
- This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
- Data Availability
- No datasets were generated or analysed during the current study.
- Grant note
- This study was jointly funded by Ministry of Agriculture and Rural Development (MARD), Vietnam (Project tittle: Breeding for disease resistance to Bacillary Necrosis of Pangasius for striped catfish, 2018 – 2020) and higher degree by research fundings from University of the Sunshine Coast, Australia.
- Organisation Unit
- School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 991127205802621
- Output Type
- Journal article
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