Journal article
Impact of eight weeks of repeated ischaemic preconditioning on brachial artery and cutaneous microcirculatory function in healthy males
European Journal of Preventive Cardiology, Vol.22(8), pp.1083-1087
2015
Abstract
Background Ischaemic preconditioning has well-established cardiac and vascular protective effects. Short interventions (one week) of daily ischaemic preconditioning episodes improve conduit and microcirculatory function. This study examined whether a longer (eight weeks) and less frequent (three per week) protocol of repeated ischaemic preconditioning improves vascular function. Methods Eighteen males were randomly allocated to either ischaemic preconditioning (22.4±2.3 years, 23.7±3.1 kg/m2) or a control intervention (26.0±4.8 years, 26.4±1.9 kg/m2). Brachial artery endothelial-dependent (FMD), forearm cutaneous microvascular function and cardiorespiratory fitness were assessed at zero, two and eight weeks. Results A greater improvement in FMD was evident following ischaemic preconditioning training compared with control at weeks 2 (2.24% (0.40, 4.08); p=0.02) and 8 (1.11% (0.13, 2.10); p=0.03). Repeated ischaemic preconditioning did not change cutaneous microcirculatory function or fitness. Conclusions These data indicate that a feasible and practical protocol of regular ischaemic preconditioning episodes improves endothelial function in healthy individuals within two weeks, and these effects persist following repeated ischaemic preconditioning for eight weeks.
Details
- Title
- Impact of eight weeks of repeated ischaemic preconditioning on brachial artery and cutaneous microcirculatory function in healthy males
- Authors
- Helen Jones (Author) - Liverpool John Moores University, United KingdomJean Nyakayiru (Author) - Radboud University Medical Centre, NetherlandsTom G Bailey (Author) - Liverpool John Moores University, United KingdomDaniel J Green (Author) - Liverpool John Moores University, United KingdomN Timothy Cable (Author) - Liverpool John Moores University, United KingdomVictoria S Sprung (Author) - Liverpool John Moores University, United KingdomNicola D Hopkins (Author) - Liverpool John Moores University, United KingdomDick H J Thijssen (Author) - Liverpool John Moores University, United Kingdom
- Publication details
- European Journal of Preventive Cardiology, Vol.22(8), pp.1083-1087
- Publisher
- Sage Publications Inc.
- Date published
- 2015
- DOI
- 10.1177/2047487314547657
- ISSN
- 2047-4881
- Copyright note
- Jones, Helen; Nyakayiru, Jean; Bailey, Tom G; Green, Daniel J; Cable, N Timothy; Sprung, Victoria S; Hopkins, Nicola D; Thijssen, Dick H J, Impact of eight weeks of repeated ischaemic preconditioning on brachial artery and cutaneous microcirculatory function in healthy males, European Journal of Preventive Cardiology (22:8) pp. 1083-1087. Copyright © 2015 The authors. Reprinted by permission of SAGE Publications.
- Organisation Unit
- UniSC Clinical Trials Centre; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
- Language
- English
- Record Identifier
- 99449920202621
- Output Type
- Journal article
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