Immunostimulatory cancer chemotherapy using local ingenol-3-angelate and synergy with immunotherapies

T T Thuy; J Gardner; D Hoang-Le; C W Schmidt; K P MacDonald; E Lambley; W A Schroder; Steven Ogbourne; A Suhrbier

doi:10.1016/j.vaccine.2009.03.025

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Immunostimulatory cancer chemotherapy using local ingenol-3-angelate and synergy with immunotherapies

Journal article

Peer reviewed

Immunostimulatory cancer chemotherapy using local ingenol-3-angelate and synergy with immunotherapies

T T Thuy, J Gardner, D Hoang-Le, C W Schmidt, K P MacDonald, E Lambley, W A Schroder, Steven Ogbourne and A Suhrbier

Vaccine, Vol.27(23), pp.3053-3062

2009

DOI: https://doi.org/10.1016/j.vaccine.2009.03.025

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Abstract

cancer vaccines

metastases

Ingenol-3-angelate is a new local chemotherapeutic agent in clinical trails that induces primary necrosis of tumour cells and transient local inflammation. Here we show that cure of subcutaneous tumours with ingenol-3-angelate (PEP005) resulted in the generation of anti-cancer CD8 T cells that could regress metastases. Furthermore, PEP005-mediated cure synergized with several CD8 T cell-based immunotherapies to regress further distant metastases. PEP005 was shown to have adjuvant properties, being able to upregulate CD80 and CD86 expression on dendritic cells in vivo, and to promote CD8 T cell induction when co-delivered with a protein antigen. PEP005 thus emerges as a unique local chemotherapeutic immunostimulatory debulking agent that could be used in conjunction with immunotherapies to promote regression of metastases.

Details

Title: Immunostimulatory cancer chemotherapy using local ingenol-3-angelate and synergy with immunotherapies
Authors: T T Thuy (Author) - Queensland Institute of Medical Research
J Gardner (Author) - Queensland Institute of Medical Research
D Hoang-Le (Author) - Queensland Institute of Medical Research
C W Schmidt (Author) - Queensland Institute of Medical Research
K P MacDonald (Author) - Queensland Institute of Medical Research
E Lambley (Author) - Queensland Institute of Medical Research
W A Schroder (Author) - Queensland Institute of Medical Research
Steven Ogbourne (Author) - Peplin Inc.
A Suhrbier (Author) - Queensland Institute of Medical Research
Publication details: Vaccine, Vol.27(23), pp.3053-3062
Publisher: Elsevier Ltd.
Date published: 2009
DOI: 10.1016/j.vaccine.2009.03.025
ISSN: 0264-410X; 0264-410X
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99449544102621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Immunology; Medicine, Research & Experimental

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