Immunopathogenesis of Chlamydia trachomatis infections in women

J Debattista; Peter Timms; John A Allan; Janet M Allan

doi:10.1016/S0015-0282(03)00396-0

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Immunopathogenesis of Chlamydia trachomatis infections in women

Journal article

Peer reviewed

Immunopathogenesis of Chlamydia trachomatis infections in women

J Debattista, Peter Timms, John A Allan and Janet M Allan

Fertility and Sterility, Vol.79(6), pp.1273-1287

2003

DOI: https://doi.org/10.1016/S0015-0282(03)00396-0

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Abstract

chlamydia trachomatis

infertility

60-kD heat shock protein

Objective: To develop a model of pathogenesis by which Chlamydia trachomatis progresses from acute to chronic infection, and finally serious disease (salpingitis, tubal occlusion). Design: Review of current literature located through web-based Medline searches using key words: Chlamydia trachomatis, immunology, cytokines, heat shock protein, infertility. Result(s): Cell-mediated immune mechanisms appear to be critical in determining whether acute infection is resolved or progresses into chronicity with pathological outcome. What determines the particular immune pathway depends on a range of determinants - HLA subtype and human genetics, cytokine profile, infectious load, route of infection, and endocrinology. A clearer picture of the natural history of chlamydial pathology may assist in providing better predictors of those women who may go on to develop significant sequelae after infection. Conclusion(s): Predicting those who may develop serious disease, including infertility, may contribute to improved management of such persons during earlier stages of infection and assist in prevention. © 2003 by American Society for Reproductive Medicine.

Details

Title: Immunopathogenesis of Chlamydia trachomatis infections in women
Authors: J Debattista (Author) - Queensland University of Technology
Peter Timms (Author) - Queensland University of Technology
John A Allan (Author) - Wesley Hospital
Janet M Allan (Author)
Publication details: Fertility and Sterility, Vol.79(6), pp.1273-1287
Publisher: Elsevier Inc.
Date published: 2003
DOI: 10.1016/S0015-0282(03)00396-0
ISSN: 0015-0282
Organisation Unit: University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99449773202621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Obstetrics & Gynecology; Reproductive Biology

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