Journal article
Immunomodulatory Function of Interleukin-15 and Its Role in Exercise, Immunotherapy, and Cancer Outcomes
Medicine and Science in Sports and Exercise, Vol.55(3), pp.558-568
2023
PMID: 36730979
Abstract
Exercise has been shown to improve physical and psychosocial outcomes for people across the cancer care continuum. A proposed mechanism underpinning the relationship between exercise and cancer outcomes is exercise induced immunomodulation via secretion of anti inflammatory myokines from skeletal muscle tissue. Myokines have the potential to impair cancer growth through modulation of natural killer (NK) cells and CD8+ T cells while improving the effectiveness of cancer therapies. Interleukin 15 (IL15), one of the most abundant myokines found in skeletal muscle, has a key immunoregulatory role in supporting the proliferation and maturation of T cells and NK cells, which have a key role in the host's immune response to cancer. Furthermore, IL15 is being explored clinically as an immunotherapy agent with doses similar to the IL15 concentrations released by skeletal muscle during exercise. Here we review the role of IL15 within the immune system, examine how IL15 is produced as a myokine during exercise, and how it may improve outcomes for people with cancer, specifically as an adjuvant or neoadjuvant to immunotherapy. We summarize the available evidence showing changes in IL15 in response to both acute exercise and training, and the results are inconsistent; higher quality research is needed to advance the understanding of how exercise mediated increases in IL15 potentially benefit those who are being treated for, or who have had, cancer.
Details
- Title
- Immunomodulatory Function of Interleukin-15 and Its Role in Exercise, Immunotherapy, and Cancer Outcomes
- Authors
- Morgan J Farley (Corresponding Author) - University of QueenslandDavid B Bartlett (Author) - University of SurreyTina L Skinner (Author) - University of QueenslandMia A Schaumberg (Author) - University of the Sunshine Coast, Queensland, School of Health - BiomedicineDavid G Jenkins (Author) - University of the Sunshine Coast, Queensland, School of Health - Sports & Exercise Science
- Publication details
- Medicine and Science in Sports and Exercise, Vol.55(3), pp.558-568
- Publisher
- Lippincott Williams & Wilkins
- Date published
- 2023
- DOI
- 10.1249/MSS.0000000000003067
- ISSN
- 1530-0315
- PMID
- 36730979
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health - Sports & Exercise Science; School of Health; Cancer Research Cluster
- Language
- English
- Record Identifier
- 99711297902621
- Output Type
- Journal article
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- Sport Sciences
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Source: InCites