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Published VersionCC BY V4.0, Open Access
Journal article
Immunomodulation of inflammatory leukocyte markers during intravenous immunoglobulin treatment associated with clinical efficacy in chronic inflammatory demyelinating polyradiculoneuropathy
Brain and Behavior, Vol.6(10), e00516
2016
Abstract
Objective: The objective of the study was to profile leukocyte markers modulated during intravenous immunoglobulin (IVIg) treatment, and to identify markers and immune pathways associated with clinical efficacy of IVIg for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) with potential for monitoring treatment efficacy. Methods: Response to IVIg treatment in newly diagnosed IVIg-naïve and established IVIg-experienced patients was assessed by changes in expression of inflammatory leukocyte markers by flow cytometry. The adjusted INCAT disability and Medical Research Council sum scores defined clinical response. Results: Intravenous immunoglobulin modulated immunopathogenic pathways associated with inflammatory disease in CIDP. Leukocyte markers of clinical efficacy included reduced CD185 + follicular helper T cells, increased regulatory markers (CD23 and CD72) on B cells, and reduction in the circulating inflammatory CD16 + myeloid dendritic cell (mDC) population and concomitant increase in CD62L and CD195 defining a less inflammatory lymphoid homing mDC phenotype. A decline in inflammatory CD16 + dendritic cells was associated with clinical improvement or stability, and correlated with magnitude of improvement in neurological assessment scores, but did not predict relapse. IVIg also induced a nonspecific improvement in regulatory and reduced inflammatory markers not associated with clinical response. Conclusions: Clinically effective IVIg modulated inflammatory and regulatory pathways associated with ongoing control or resolution of CIDP disease. Some of these markers have potential for monitoring outcome.
Details
- Title
- Immunomodulation of inflammatory leukocyte markers during intravenous immunoglobulin treatment associated with clinical efficacy in chronic inflammatory demyelinating polyradiculoneuropathy
- Authors
- W B Dyer (Author) - Australian Red Cross Blood ServiceJ C G Tan (Author) - Australian Red Cross Blood ServiceT Day (Author) - The Royal Melbourne HospitalL Kiers (Author) - The Royal Melbourne HospitalM C Kiernan (Author) - The University of SydneyC Yiannikas (Author) - Burwest Neurophysiology ServicesS Reddel (Author) - The University of SydneyK Ng (Author) - The University of SydneyP Mondy (Author) - Australian Red Cross Blood ServiceP M Dennington (Author) - Australian Red Cross Blood ServiceMelinda M Dean (Author) - Australian Red Cross Blood ServiceH M Trist (Author) - Burnet InstituteC dos Remedios (Author) - The University of SydneyP M Hogarth (Author) - Burnet InstituteS Vucic (Author) - The University of SydneyD O Irving (Author) - Australian Red Cross Blood Service
- Publication details
- Brain and Behavior, Vol.6(10), e00516
- Publisher
- John Wiley & Sons Ltd.
- Date published
- 2016
- DOI
- 10.1002/brb3.516
- ISSN
- 2162-3279; 2162-3279
- Copyright note
- Copyright © 2016 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Organisation Unit
- School of Health - Biomedicine; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99450635902621
- Output Type
- Journal article
- Research Statement
- false
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