Immunohistochemical Detection of Survivin in Canine Lymphoma

J Wimmershoff; Adam Polkinghorne; P Grest; B Schade; T Marchal; S M Keller; F Guscetti

doi:10.1016/j.jcpa.2009.12.004

Back

Immunohistochemical Detection of Survivin in Canine Lymphoma

Journal article

Peer reviewed

Immunohistochemical Detection of Survivin in Canine Lymphoma

J Wimmershoff, Adam Polkinghorne, P Grest, B Schade, T Marchal, S M Keller and F Guscetti

Journal of Comparative Pathology, Vol.142(4), pp.311-322

2010

DOI: https://doi.org/10.1016/j.jcpa.2009.12.004

Files and links (1)

url

https://doi.org/10.1016/j.jcpa.2009.12.004View

Published Version

Abstract

dog

immunohistochemistry

lymphoma

survivin

Survivin is a member of the family of proteins known as 'inhibitors of apoptosis proteins'. Survivin has a role in cellular decisions concerning division and survival and is frequently expressed in neoplastic cells. The aim of the present study was to investigate immunohistochemically the expression of survivin in normal canine tissues and in canine lymphoma. A representative range of fetal and adult normal tissues as well as biopsy samples from dogs with lymphoma were assembled in tissue arrays. The lymphomas were classified according to the revised Kiel and to the Revised European American Lymphoma - World Health Organization (REAL-WHO) schemes. Polyclonal and monoclonal antisera cross-reactive with canine survivin identified cytoplasmic expression of the molecule in a broad range of normal canine cells. The same reagents demonstrated cytoplasmic labelling of more than 5% of cells in all 83 lymphoma samples tested with polyclonal antiserum and in 67 of 82 (82%) of samples tested with monoclonal antiserum. Survivin was expressed by a wide range of canine lymphoma subtypes, but the expression of this molecule in normal canine tissues must be considered if novel therapies targeting survivin are applied to the management of canine lymphoma. © 2010 Elsevier Ltd.

Details

Title: Immunohistochemical Detection of Survivin in Canine Lymphoma
Authors: J Wimmershoff (Author) - University of Zurich, Switzerland
Adam Polkinghorne (Author) - University of Zurich, Switzerland
P Grest (Author) - University of Zurich, Switzerland
B Schade (Author) - University of Zurich, Switzerland
T Marchal (Author) - Ecole Nationale Vétérinaire de Lyon, France
S M Keller (Author) - University of Zurich, Switzerland
F Guscetti (Author) - University of Zurich, Switzerland
Publication details: Journal of Comparative Pathology, Vol.142(4), pp.311-322
Publisher: Elsevier Ltd.
Date published: 2010
DOI: 10.1016/j.jcpa.2009.12.004
ISSN: 0021-9975
Organisation Unit: University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99448652802621
Output Type: Journal article

Metrics

2 File views/ downloads

413 Record Views

11 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Pathology; Veterinary Sciences

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites