Immunity against a Chlamydia infection and disease may be determined by a balance of IL-17 signaling

C P O'Meara; C W Armitage; M C Harvie; D W Andrew; Peter Timms; N Y Lycke; K W Beagley

doi:10.1038/icb.2013.92

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Immunity against a Chlamydia infection and disease may be determined by a balance of IL-17 signaling

Journal article

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Peer reviewed

Immunity against a Chlamydia infection and disease may be determined by a balance of IL-17 signaling

C P O'Meara, C W Armitage, M C Harvie, D W Andrew, Peter Timms, N Y Lycke and K W Beagley

Immunology and Cell Biology, Vol.92, pp.287-297

2014

DOI: https://doi.org/10.1038/icb.2013.92

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Abstract

adjuvant

Chlamydia

intranasal

sublingual

transcutaneous

vaccine

Most vaccines developed against Chlamydia using animal models provide partial protection against a genital tract infection. However, protection against the oviduct pathology associated with infertility is highly variable and often has no defining immunological correlate. When comparing two adjuvants (CTA1-DD and a combination of Cholera toxin plus CpG-oligodeoxynucleotide-CT/CpG) combined with the chlamydial major outer membrane protein (MOMP) antigen and delivered via the intranasal (IN), sublingual (SL) or transcutaneous (TC) routes, we identified two vaccine groups with contrasting outcomes following infection. SL immunization with MOMP/CTA1-DD induced a 70% reduction in the incidence of oviduct pathology, without significantly altering the course of infection. Conversely, IN immunization with MOMP/CT/CpG prevented an ascending infection, but not the oviduct pathology. This anomaly presented a unique opportunity to study the mechanisms by which vaccines can prevent oviduct pathology, other than by controlling the infection. The IL-17 signaling in the oviducts was found to associate with both the enhancement of immunity to infection and the development of oviduct pathology. This conflicting role of IL-17 may provide some explanation for the discordance in protection between infection and disease and suggests that controlling immunopathology, as opposed to the rapid eradication of the infection, may be essential for an effective human chlamydial vaccine that prevents infertility.

Details

Title: Immunity against a Chlamydia infection and disease may be determined by a balance of IL-17 signaling
Authors: C P O'Meara (Author) - Queensland University of Technology
C W Armitage (Author) - Queensland University of Technology
M C Harvie (Author) - Queensland University of Technology
D W Andrew (Author) - Queensland University of Technology
Peter Timms (Author) - Queensland University of Technology
N Y Lycke (Author) - University of Gothenburg, Sweden
K W Beagley (Author) - Queensland University of Technology
Publication details: Immunology and Cell Biology, Vol.92, pp.287-297
Publisher: Nature Publishing Group
Date published: 2014
DOI: 10.1038/icb.2013.92
ISSN: 0818-9641
Copyright note: Copyright © 2014 Nature Publishing Group. The accepted version is reproduced here in accordance with the publishers copyright policy. The definitive version is available from http://www.nature.com/icb/
Organisation Unit: University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99448771502621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Cell Biology; Immunology

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