Immunisation of koalas against Chlamydia pecorum results in significant protection against chlamydial disease and mortality

Samuel Phillips; Jon Hanger; Julien Grosmaire; Ahmed Mehdi; Martina Jelocnik; Jessie Wong; Peter Timms

doi:10.1038/s41541-024-00938-5

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Immunisation of koalas against Chlamydia pecorum results in significant protection against chlamydial disease and mortality

Journal article

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Immunisation of koalas against Chlamydia pecorum results in significant protection against chlamydial disease and mortality

Samuel Phillips, Jon Hanger, Julien Grosmaire, Ahmed Mehdi, Martina Jelocnik, Jessie Wong and Peter Timms

npj Vaccines, Vol.9, pp.1-6

2024

DOI: https://doi.org/10.1038/s41541-024-00938-5

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Abstract

clinical microbiology

vaccines

In 2022, the Australian Government listed the koala as endangered in several states due to habitat destruction, traffic strikes, dog attacks, and Chlamydia pecorum disease. This study evaluates a 10-year assessment of a Major Outer Membrane Protein-based vaccine's effectiveness against chlamydial disease in wild koalas from Southeast Queensland. Over a decade, 680 koalas were tracked, with five vaccine trials involving 165 koalas. While prior studies only offered up to two years of data, this study's extended period allowed a thorough evaluation of vaccine efficacy. Results showed that vaccinated koalas had significantly lower disease incidence, with a 64% reduction in chlamydial mortality. This vaccine demonstrated positive impacts on both male and female koalas, highlighting its crucial role in conserving the Australian koala population and mitigating the threats they face.In 2022, the Australian Government listed the koala as endangered in several states due to habitat destruction, traffic strikes, dog attacks, and Chlamydia pecorum disease. This study evaluates a 10-year assessment of a Major Outer Membrane Protein-based vaccine's effectiveness against chlamydial disease in wild koalas from Southeast Queensland. Over a decade, 680 koalas were tracked, with five vaccine trials involving 165 koalas. While prior studies only offered up to two years of data, this study's extended period allowed a thorough evaluation of vaccine efficacy. Results showed that vaccinated koalas had significantly lower disease incidence, with a 64% reduction in chlamydial mortality. This vaccine demonstrated positive impacts on both male and female koalas, highlighting its crucial role in conserving the Australian koala population and mitigating the threats they face.

Details

Title: Immunisation of koalas against Chlamydia pecorum results in significant protection against chlamydial disease and mortality
Authors: Samuel Phillips (Corresponding Author) - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Jon Hanger - Endeavour Veterinary Ecology Pty Ltd
Julien Grosmaire - Endeavour Veterinary Ecology Pty Ltd
Ahmed Mehdi - QCIF Ltd.
Martina Jelocnik - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Jessie Wong - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Peter Timms - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Publication details: npj Vaccines, Vol.9, pp.1-6
Publisher: Nature Publishing Group
Date published: 2024
DOI: 10.1038/s41541-024-00938-5
ISSN: 2059-0105
Copyright note: This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
Data Availability: All data is available within the manuscript and supplementary files.
Grant note: Australian Research Council (ARC): LP1202000051
Organisation Unit: School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 991053072502621
Output Type: Journal article

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