Immune response to superoxide dismutase in group A streptococcal infection

David J McMillan; M R Davies; M F Good; K S Sriprakash

doi:10.1016/S0928-8244(04)00003-3

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Immune response to superoxide dismutase in group A streptococcal infection

Journal article

Peer reviewed

Immune response to superoxide dismutase in group A streptococcal infection

David J McMillan, M R Davies, M F Good and K S Sriprakash

FEMS Immunology and Medical Microbiology, Vol.40(3), pp.249-256

2004

DOI: https://doi.org/10.1016/S0928-8244(04)00003-3

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Abstract

Cardiovascular Medicine and Haematology

Immunology

Medical Microbiology

group A streptococcus

superoxide dismutase

Extracellular localisation of manganese-dependent superoxide dismutase (SodA) by group A streptococcus (GAS) may have a role in protection of this pathogenic bacterium from exogenously produced reactive oxygen species. In this study we show that SodA is found both in surface protein extracts and in culture supernatants of GAS. To investigate whether SodA is a possible vaccine candidate outbred Quackenbush mice were subcutaneously vaccinated with recombinant SodA. Strong antibody responses which were moderately opsonic were elicited. These antibodies were unable to protect mice from intraperitoneal challenge with M1 GAS. We also show that SodA and p145 (a conserved peptide from the M-protein) antibodies are present at significantly higher levels amongst patients with rheumatic heart disease than in control subjects from the same endemic region. The higher SodA antibody levels in patients may be indicative of a role for this protein in pathogenesis of rheumatic heart disease but are more likely to be a marker of recent or recurrent streptococcal infection.

Details

Title: Immune response to superoxide dismutase in group A streptococcal infection
Authors: David J McMillan (Author) - Queensland Institute of Medical Research
M R Davies (Author) - Queensland Institute of Medical Research
M F Good (Author) - Queensland Institute of Medical Research
K S Sriprakash (Author) - Queensland Institute of Medical Research
Publication details: FEMS Immunology and Medical Microbiology, Vol.40(3), pp.249-256
Publisher: Wiley-Blackwell Publishing Ltd.
Date published: 2004
DOI: 10.1016/S0928-8244(04)00003-3
ISSN: 0928-8244
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450051002621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Immunology; Infectious Diseases; Microbiology

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