Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

R A Eeles; Z Kote-Jarai; A A Al Olama; G G Giles; M Guy; G Severi; K Muir; J L Hopper; B E Henderson; C A Haiman; J Schleutker; F C Hamdy; D E Neal; Jenny L Donovan; J L Stanford; E A Ostrander; S A Ingles; E M John; S N Thibodeau; D Schaid; J Y Park; A Spurdle; J Clements; J L Dickinson; C Maier; W Vogel; T Dörk; T R Rebbeck; K A Cooney; L Cannon-Albright; P O Chappuis; P Hutter; M Zeegers; R Kaneva; H W Zhang; Y J Lu; W D Foulkes; D R English; D A Leongamornlert; M Tymrakiewicz; J Morrison; A T Ardern-Jones; A L Hall; L T O'Brien; R A Wilkinson; E J Saunders; E C Page; E J Sawyer; S M Edwards; D P Dearnaley; A Horwich; R A Huddart; V S Khoo; C C Parker; N Van As; C J Woodhouse; A Thompson; T Christmas; C Ogden; C S Cooper; M C Southey; A Lophatananon; J F Liu; L N Kolonel; L Le Marchand; T Wahlfors; T L Tammela; A Auvinen; S J Lewis; A Cox; L M Fitzgerald; J S Koopmeiners; D M Karyadi; E M Kwon; M C Stern; R Corral; A D Joshi; A Shahabi; S K McDonnell; T A Sellers; J Pow-Sang; S Chambers; J Aitken; R A Gardiner; J Batra; M A Kedda; Felicity Lose; A Polanowski; B Patterson; J Serth; A Meyer; M Luedeke; K Stefflova; A M Ray; E M Lange; J Farnham; H Khan; C Slavov; A Mitkova; G Cao; D F Easton

doi:10.1038/ng.450

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Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

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Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

R A Eeles, Z Kote-Jarai, A A Al Olama, G G Giles, M Guy, G Severi, K Muir, J L Hopper, B E Henderson, C A Haiman, …

Nature Genetics, Vol.41(10), pp.1116-1121

2009

DOI: https://doi.org/10.1038/ng.450

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Abstract

Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 × 10 8 to P = 2.7 × 10 33). © 2009 Nature America, Inc. All rights reserved.

Details

Title: Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
Authors: R A Eeles (Author)
Z Kote-Jarai (Author)
A A Al Olama (Author)
G G Giles (Author)
M Guy (Author)
G Severi (Author)
K Muir (Author)
J L Hopper (Author)
B E Henderson (Author)
C A Haiman (Author)
J Schleutker (Author)
F C Hamdy (Author)
D E Neal (Author)
Jenny L Donovan (Author)
J L Stanford (Author)
E A Ostrander (Author)
S A Ingles (Author)
E M John (Author)
S N Thibodeau (Author)
D Schaid (Author)
J Y Park (Author)
A Spurdle (Author)
J Clements (Author)
J L Dickinson (Author)
C Maier (Author)
W Vogel (Author)
T Dörk (Author)
T R Rebbeck (Author)
K A Cooney (Author)
L Cannon-Albright (Author)
P O Chappuis (Author)
P Hutter (Author)
M Zeegers (Author)
R Kaneva (Author)
H W Zhang (Author)
Y J Lu (Author)
W D Foulkes (Author)
D R English (Author)
D A Leongamornlert (Author)
M Tymrakiewicz (Author)
J Morrison (Author)
A T Ardern-Jones (Author)
A L Hall (Author)
L T O'Brien (Author)
R A Wilkinson (Author)
E J Saunders (Author)
E C Page (Author)
E J Sawyer (Author)
S M Edwards (Author)
D P Dearnaley (Author)
A Horwich (Author)
R A Huddart (Author)
V S Khoo (Author)
C C Parker (Author)
N Van As (Author)
C J Woodhouse (Author)
A Thompson (Author)
T Christmas (Author)
C Ogden (Author)
C S Cooper (Author)
M C Southey (Author)
A Lophatananon (Author)
J F Liu (Author)
L N Kolonel (Author)
L Le Marchand (Author)
T Wahlfors (Author)
T L Tammela (Author)
A Auvinen (Author)
S J Lewis (Author)
A Cox (Author)
L M Fitzgerald (Author)
J S Koopmeiners (Author)
D M Karyadi (Author)
E M Kwon (Author)
M C Stern (Author)
R Corral (Author)
A D Joshi (Author)
A Shahabi (Author)
S K McDonnell (Author)
T A Sellers (Author)
J Pow-Sang (Author)
S Chambers (Author)
J Aitken (Author)
R A Gardiner (Author)
J Batra (Author)
M A Kedda (Author)
Felicity Lose (Author) - Queensland Institute of Medical Research
A Polanowski (Author)
B Patterson (Author)
J Serth (Author)
A Meyer (Author)
M Luedeke (Author)
K Stefflova (Author)
A M Ray (Author)
E M Lange (Author)
J Farnham (Author)
H Khan (Author)
C Slavov (Author)
A Mitkova (Author)
G Cao (Author)
D F Easton (Author)
Publication details: Nature Genetics, Vol.41(10), pp.1116-1121
Publisher: Nature Publishing Group
Date published: 2009
DOI: 10.1038/ng.450
ISSN: 1061-4036
Copyright note: Copyright © 2009 Nature Publishing Group. The accepted version is reproduced here in accordance with the publishers copyright policy. The definitive version is available from https://www.nature.com/ng/
Organisation Unit: University of the Sunshine Coast, Queensland; Office of Research
Language: English
Record Identifier: 99450469902621
Output Type: Journal article

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