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Accepted VersionCC BY-NC-ND V4.0, Open Access
Journal article
Identification of neuropeptides in sea cucumber Holothuria leucospilota
General and Comparative Endocrinology, Vol.283, 113229
2019
Abstract
Neuropeptides play important roles in the regulation of physiological processes such as growth, metabolism and reproduction. In sea cucumbers (Phylum Echinodermata), numerous neuropeptides have been identified and some are attributed to reproductive processes. In this study, our goal was to gain a better understanding of the neuropeptide repertoire for the black sea cucumber Holothuria leucospilota, a species that has been severely overfished from the wild due to human consumption. We applied in silico transcriptome analysis of the adult H. leucospilota radial nerve cord, gonad and body wall to elucidate 37 neuropeptides that are conserved throughout the Bilateria. Then, liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis of radial nerve cord was employed and showed an additional 8 putative novel neuropeptide precursors, whose predicative cleaved peptides do not share sequence similarity with any reported neuropeptides. These data provide an important basis for experimental approaches to manipulate H. leucospilota broodstock reproduction and growth in culture, which will hopefully re-establish population numbers.
Details
- Title
- Identification of neuropeptides in sea cucumber Holothuria leucospilota
- Authors
- Chieu Hoang Dinh (Author) - University of the Sunshine CoastSaowaros Suwansa-ard (Author) - University of the Sunshine CoastTianfang Wang (Author) - University of the Sunshine CoastAbigail Elizur (Author) - University of the Sunshine CoastScott F Cummins (Author) - University of the Sunshine Coast
- Publication details
- General and Comparative Endocrinology, Vol.283, 113229
- Publisher
- Academic Press
- Date published
- 2019
- DOI
- 10.1016/j.ygcen.2019.113229
- ISSN
- 0016-6480; 0016-6480
- Copyright note
- Copyright © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99451493602621
- Output Type
- Journal article
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- International collaboration
- Web Of Science research areas
- Endocrinology & Metabolism
- Zoology
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