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Journal article
Identification of Acetomycin as an Antifungal Agent Produced by Termite Gut-Associated Streptomycetes against Pyrrhoderma noxium
Antibiotics, Vol.13(1), pp.1-14
2024
PMID: 38247604
Abstract
Plant fungal pathogen Pyrrhoderma noxium is responsible for the destructive and invasive disease of brown root rot currently affecting the city of Brisbane, Australia. In order to address this issue, environmentally friendly and safe alternatives to chemical control are preferred due to the city’s public setting. Antifungal natural products are ideal candidates as biological control alternatives and can be detected through investigating the metabolomes of microbial symbionts. Within this study, an NMR-based metabolomics approach was applied to fermentation extracts obtained from 15 termite gut-associated streptomycetes. By analysing the NMR spectra, six of the extracts which displayed similar chemical profiles exhibited antifungal activity against the P. noxium pathogen. The major compound within these extracts was identified as acetomycin using NMR and X-ray crystallography analyses. This is the first reporting of acetomycin as a potential natural product fungicide, particularly as an antifungal agent against P. noxium. Inhibitory activity was also found against other important fungal crop pathogens, including Aspergillus niger, Botrytis cinerea, and Alteranaria alternata. Further experimentation using a woodblock test found inhibitory activity on the growth of the P. noxium pathogen for up to 3 weeks and a significant difference in the integrity of the woodblocks when conducting compression strength tests after 6 weeks. Therefore, acetomycin may be used as a biological control agent and natural product fungicide against P. noxium.
Details
- Title
- Identification of Acetomycin as an Antifungal Agent Produced by Termite Gut-Associated Streptomycetes against Pyrrhoderma noxium
- Authors
- Cherrihan Adra (Author) - University of the Sunshine Coast, Queensland, School of Science, Technology and EngineeringTrong D. Tran (Author) - University of the Sunshine Coast, Queensland, Centre for BioinnovationKeith Foster (Author) - Brisbane City CouncilRussell Tomlin (Author) - Brisbane City CouncilD. İpek Kurtböke (Corresponding Author) - University of the Sunshine Coast, Queensland, School of Science, Technology and Engineering
- Publication details
- Antibiotics, Vol.13(1), pp.1-14
- Publisher
- MDPI AG
- Date published
- 2024
- DOI
- 10.3390/antibiotics13010045
- ISSN
- 2079-6382
- PMID
- 38247604
- Copyright note
- © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Data Availability
- Data are contained within the article.
- Grant note
- This research was funded by Brisbane City Council, grant number R22_0098.
- Organisation Unit
- School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99993596402621
- Output Type
- Journal article
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