Identification of A Novel Picorna-Like Virus, Burpengary Virus, that is Negatively Associated with Chlamydial Disease in the Koala

Erin Harvey; Danielle Madden; Adam Polkinghorne; Edward C Holmes

doi:10.3390/v11030211

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Identification of A Novel Picorna-Like Virus, Burpengary Virus, that is Negatively Associated with Chlamydial Disease in the Koala

Journal article

Open access

Peer reviewed

Identification of A Novel Picorna-Like Virus, Burpengary Virus, that is Negatively Associated with Chlamydial Disease in the Koala

Erin Harvey, Danielle Madden, Adam Polkinghorne and Edward C Holmes

Viruses, Vol.11(3), 211

2019

DOI: https://doi.org/10.3390/v11030211

PMCID: PMC6466430

PMID: 30832350

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Abstract

virus discovery

Chlamydia pecorum

koala

picornavirus

phylogeny

Koalas (Phascolarctos cinereus) are native Australian marsupials whose populations are in decline from a range of threats. Infectious diseases caused by the bacterium Chlamydia pecorum and other pathogens are of particular concern. We analysed 26 poly-A selected RNA-sequencing libraries from a data set designed to study the immune response of koalas to ocular chlamydial infection. Using virus discovery techniques, we identified the coding-complete genome sequence of a novel picorna-like virus, denoted Burpengary virus, that was most common in south-east Queensland. Notably, abundance measurements of the virus across all 26 libraries revealed an inverse relationship between abundance and ocular disease in koalas, suggesting that the co-infection of Burpengary virus and Chlamydia pecorum is inhibited.

Details

Title: Identification of A Novel Picorna-Like Virus, Burpengary Virus, that is Negatively Associated with Chlamydial Disease in the Koala
Authors: Erin Harvey (Author) - University of Sydney
Danielle Madden (Author) - University of the Sunshine Coast - School of Science & Engineering
Adam Polkinghorne (Author) - University of the Sunshine Coast - School of Science & Engineering
Edward C Holmes (Author) - University of Sydney
Publication details: Viruses, Vol.11(3), 211
Publisher: MDPI AG
Date published: 2019
DOI: 10.3390/v11030211
ISSN: 1999-4915
PMID: 30832350; PMC6466430
Copyright note: Copyright © 2019 The Authors. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering
Language: English
Record Identifier: 99451265702621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Virology

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