Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

R A Eeles; A A A Olama; S Benlloch; E J Saunders; D A Leongamornlert; M Tymrakiewicz; M Ghoussaini; C Luccarini; J Dennis; S Jugurnauth-Little; T Dadaev; D E Neal; F C Hamdy; Jenny L Donovan; K Muir; G G Giles; G Severi; F Wiklund; H Gronberg; C A Haiman; F Schumacher; B E Henderson; L Le Marchand; S Lindstrom; P Kraft; D J Hunter; S Gapstur; S J Chanock; S I Berndt; D Albanes; G Andriole; J Schleutker; M Weischer; F Canzian; E Riboli; T J Key; R C Travis; D Campa; S A Ingles; E M John; R B Hayes; P D P Pharoah; N Pashayan; K T Khaw; J L Stanford; E A Ostrander; L B Signorello; S N Thibodeau; D Schaid; C Maier; W Vogel; A S Kibel; C Cybulski; J Lubinski; L Cannon-Albright; H Brenner; J Y Park; R Kaneva; J Batra; A B Spurdle; J A Clements; M R Teixeira; E Dicks; A Lee; A M Dunning; C Baynes; D Conroy; M J Maranian; S Ahmed; K Govindasami; M Guy; R A Wilkinson; E J Sawyer; Angela Morgan; D P Dearnaley; A Horwich; R A Huddart; V S Khoo; C C Parker; N J Van As; C J Woodhouse; A Thompson; T Dudderidge; C Ogden; C S Cooper; A Lophatananon; A Cox; M C Southey; J L Hopper; D R English; M Aly; J Adolfsson; J Xu; S L Zheng; M Yeager; R Kaaks; W R Diver; M M Gaudet; M C Stern; R Corral; A D Joshi; A Shahabi; T Wahlfors; T L J Tammela; A Auvinen; J Virtamo; P Klarskov; Bø G Nordestgaard; M A Røder; S F Nielsen; S E Bojesen; A Siddiq; L M Fitzgerald; S Kolb; E M Kwon; D M Karyadi; W J Blot; W Zheng; Q Cai; S K McDonnell; A E Rinckleb; B Drake; G Colditz; D Wokolorczyk; R A Stephenson; C Teerlink; H Muller; D Rothenbacher; T A Sellers; H Y Lin; C Slavov; V Mitev; Felicity Lose; S Srinivasan; S Maia; P Paulo; E Lange; K A Cooney; A C Antoniou; D Vincent; F Bacot; D C Tessier; Z Kote-Jarai; D F Easton

doi:10.1038/ng.2560

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Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

Journal article

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Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

R A Eeles, A A A Olama, S Benlloch, E J Saunders, D A Leongamornlert, M Tymrakiewicz, M Ghoussaini, C Luccarini, J Dennis, S Jugurnauth-Little, …

Nature Genetics, Vol.45(4), pp.385-391

2013

DOI: https://doi.org/10.1038/ng.2560

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Abstract

Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10 -8). More than 70 prostate cancer susceptibility loci, explaining ∼30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.

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Title: Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array
Authors: R A Eeles (Author)
A A A Olama (Author)
S Benlloch (Author)
E J Saunders (Author)
D A Leongamornlert (Author)
M Tymrakiewicz (Author)
M Ghoussaini (Author)
C Luccarini (Author)
J Dennis (Author)
S Jugurnauth-Little (Author)
T Dadaev (Author)
D E Neal (Author)
F C Hamdy (Author)
Jenny L Donovan (Author)
K Muir (Author)
G G Giles (Author)
G Severi (Author)
F Wiklund (Author)
H Gronberg (Author)
C A Haiman (Author)
F Schumacher (Author)
B E Henderson (Author)
L Le Marchand (Author)
S Lindstrom (Author)
P Kraft (Author)
D J Hunter (Author)
S Gapstur (Author)
S J Chanock (Author)
S I Berndt (Author)
D Albanes (Author)
G Andriole (Author)
J Schleutker (Author)
M Weischer (Author)
F Canzian (Author)
E Riboli (Author)
T J Key (Author)
R C Travis (Author)
D Campa (Author)
S A Ingles (Author)
E M John (Author)
R B Hayes (Author)
P D P Pharoah (Author)
N Pashayan (Author)
K T Khaw (Author)
J L Stanford (Author)
E A Ostrander (Author)
L B Signorello (Author)
S N Thibodeau (Author)
D Schaid (Author)
C Maier (Author)
W Vogel (Author)
A S Kibel (Author)
C Cybulski (Author)
J Lubinski (Author)
L Cannon-Albright (Author)
H Brenner (Author)
J Y Park (Author)
R Kaneva (Author)
J Batra (Author)
A B Spurdle (Author)
J A Clements (Author)
M R Teixeira (Author)
E Dicks (Author)
A Lee (Author)
A M Dunning (Author)
C Baynes (Author)
D Conroy (Author)
M J Maranian (Author)
S Ahmed (Author)
K Govindasami (Author)
M Guy (Author)
R A Wilkinson (Author)
E J Sawyer (Author)
Angela Morgan (Author)
D P Dearnaley (Author)
A Horwich (Author)
R A Huddart (Author)
V S Khoo (Author)
C C Parker (Author)
N J Van As (Author)
C J Woodhouse (Author)
A Thompson (Author)
T Dudderidge (Author)
C Ogden (Author)
C S Cooper (Author)
A Lophatananon (Author)
A Cox (Author)
M C Southey (Author)
J L Hopper (Author)
D R English (Author)
M Aly (Author)
J Adolfsson (Author)
J Xu (Author)
S L Zheng (Author)
M Yeager (Author)
R Kaaks (Author)
W R Diver (Author)
M M Gaudet (Author)
M C Stern (Author)
R Corral (Author)
A D Joshi (Author)
A Shahabi (Author)
T Wahlfors (Author)
T L J Tammela (Author)
A Auvinen (Author)
J Virtamo (Author)
P Klarskov (Author)
Bø G Nordestgaard (Author)
M A Røder (Author)
S F Nielsen (Author)
S E Bojesen (Author)
A Siddiq (Author)
L M Fitzgerald (Author)
S Kolb (Author)
E M Kwon (Author)
D M Karyadi (Author)
W J Blot (Author)
W Zheng (Author)
Q Cai (Author)
S K McDonnell (Author)
A E Rinckleb (Author)
B Drake (Author)
G Colditz (Author)
D Wokolorczyk (Author)
R A Stephenson (Author)
C Teerlink (Author)
H Muller (Author)
D Rothenbacher (Author)
T A Sellers (Author)
H Y Lin (Author)
C Slavov (Author)
V Mitev (Author)
Felicity Lose (Author) - Queensland Institute of Medical Research
S Srinivasan (Author)
S Maia (Author)
P Paulo (Author)
E Lange (Author)
K A Cooney (Author)
A C Antoniou (Author)
D Vincent (Author)
F Bacot (Author)
D C Tessier (Author)
Z Kote-Jarai (Author)
D F Easton (Author)
Publication details: Nature Genetics, Vol.45(4), pp.385-391
Publisher: Nature Publishing Group
Date published: 2013
DOI: 10.1038/ng.2560
ISSN: 1061-4036
Copyright note: Copyright © 2013 Nature Publishing Group. The accepted version is reproduced here in accordance with the publishers copyright policy. The definitive version is available from https://www.nature.com/ng/
Organisation Unit: University of the Sunshine Coast, Queensland; Office of Research
Language: English
Record Identifier: 99450931402621
Output Type: Journal article

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