IMI-The Dynamic Choroid: New Insights, Challenges, and Potential Significance for Human Myopia

Lisa A. Ostrin; Elise Harb; Debora L. Nickla; Scott A. Read; David Alonso-Caneiro; Falk Schroedl; Alexandra Kaser-Eichberger; Xiangtian Zhou; Christine F. Wildsoet

doi:10.1167/iovs.64.6.4

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IMI-The Dynamic Choroid: New Insights, Challenges, and Potential Significance for Human Myopia

Journal article

Open access

Peer reviewed

IMI-The Dynamic Choroid: New Insights, Challenges, and Potential Significance for Human Myopia

Lisa A. Ostrin, Elise Harb, Debora L. Nickla, Scott A. Read, David Alonso-Caneiro, Falk Schroedl, Alexandra Kaser-Eichberger, Xiangtian Zhou and Christine F. Wildsoet

Investigative Ophthalmology & Visual Science, Vol.64(6), pp.1-21

2023

DOI: https://doi.org/10.1167/iovs.64.6.4

PMID: 37126359

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Abstract

myopia control

myopia progression

myopia management

choroid

The choroid is the richly vascular layer of the eye located between the sclera and Bruch’s membrane. Early studies in animals, as well as more recent studies in humans, have demonstrated that the choroid is a dynamic, multifunctional structure, with its thickness directly and indirectly subject to modulation by a variety of physiologic and visual stimuli. In this review, the anatomy and function of the choroid are summarized and links between the choroid, eye growth regulation, and myopia, as demonstrated in animal models, discussed. Methods for quantifying choroidal thickness in the human eye and associated challenges are described, the literature examining choroidal changes in response to various visual stimuli and refractive error-related differences are summarized, and the potential implications of the latter for myopia are considered. This review also allowed for the reexamination of the hypothesis that short-term changes in choroidal thickness induced by pharmacologic, optical, or environmental stimuli are predictive of future long-term changes in axial elongation, and the speculation that short-term choroidal thickening can be used as a biomarker of treatment efficacy for myopia control therapies, with the general conclusion that current evidence is not sufficient.

Details

Title: IMI-The Dynamic Choroid: New Insights, Challenges, and Potential Significance for Human Myopia
Authors: Lisa A. Ostrin (Corresponding Author) - University of Houston
Elise Harb (Author) - University of California, Berkeley
Debora L. Nickla (Author) - New England College of Optometry
Scott A. Read (Author) - Queensland University of Technology
David Alonso-Caneiro (Author) - Queensland University of Technology
Falk Schroedl (Author) - Paracelsus Medical University
Alexandra Kaser-Eichberger (Author) - Paracelsus Medical University
Xiangtian Zhou (Author) - Wenzhou Medical University
Christine F. Wildsoet (Author) - University of California, Berkeley
Publication details: Investigative Ophthalmology & Visual Science, Vol.64(6), pp.1-21
Publisher: Association for Research in Vision and Ophthalmology
Date published: 2023
DOI: 10.1167/iovs.64.6.4
ISSN: 1552-5783; 0146-0404
PMID: 37126359
Copyright note: Copyright 2023 The Authors. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Organisation Unit: School of Science, Technology and Engineering
Language: English
Record Identifier: 99972397102621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Ophthalmology

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