IL-10 signalling blockade at the time of immunization inhibits Human papillomavirus 16 E7 transformed TC-1 tumour cells growth in mice

Shu Chen; Xiongfei Wang; Xiaolian Wu; Ming Q Wei; Bin Zhang; Xiao Song Liu; Yuejian Wang

doi:10.1016/j.cellimm.2014.06.002

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IL-10 signalling blockade at the time of immunization inhibits Human papillomavirus 16 E7 transformed TC-1 tumour cells growth in mice

Journal article

Peer reviewed

IL-10 signalling blockade at the time of immunization inhibits Human papillomavirus 16 E7 transformed TC-1 tumour cells growth in mice

Shu Chen, Xiongfei Wang, Xiaolian Wu, Ming Q Wei, Bin Zhang, Xiao Song Liu and Yuejian Wang

Cellular Immunology, Vol.290(1), pp.145-151

2014

DOI: https://doi.org/10.1016/j.cellimm.2014.06.002

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Abstract

IL10

Immunotherapy

Cervical cancer

IL-10 signalling blockade by intra-peritoneal injection of anti-IL-10 receptor antibodies at the time of immunization enhances vaccine induced CD8+ T cell responses and promotes bacteria, parasitic and viral control. We now show that blockade of IL-10 signalling at the time of immunization enhances vaccine induced antigen specific CD8+ T cell responses to both dominant and subdominant CTL epitopes. Injection of anti-IL-10 receptor antibodies subcutaneous at the time of immunization also enhances CD8+ T cell responses. Furthermore, IL-10 signalling blockade at the time of a Human papillomavirus 16 E7 peptide/LPS immunization, prevents HPV16 E7 transformed TC-1 tumour growth in mice. Immunization in the presence of anti-IL-10R antibodies and Monophosphoryl lipid A, generates antigen specific CD8+ T cell responses similar to immunization with LPS. Our results suggest that immunization and IL-10 signalling blockade may provide a novel way for the development of therapeutic vaccines against cancer.

Details

Title: IL-10 signalling blockade at the time of immunization inhibits Human papillomavirus 16 E7 transformed TC-1 tumour cells growth in mice
Authors: Shu Chen (Author) - Cancer Research Institute, Foshan First People's Hospital, China
Xiongfei Wang (Author) - Cancer Research Institute, Foshan First People's Hospital, China
Xiaolian Wu (Author) - Cancer Research Institute, Foshan First People's Hospital, China
Ming Q Wei (Author) - Griffith University
Bin Zhang (Author) - Cancer Research Institute, Foshan First People's Hospital, China
Xiao Song Liu (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Yuejian Wang (Author) - Cancer Research Institute, Foshan First People's Hospital, China
Publication details: Cellular Immunology, Vol.290(1), pp.145-151
Publisher: Academic Press
Date published: 2014
DOI: 10.1016/j.cellimm.2014.06.002
ISSN: 0008-8749
Organisation Unit: University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy
Language: English
Record Identifier: 99448770702621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Cell Biology; Immunology

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