Journal article
Hypertrophic Cardiomyopathy: Challenging the Status Quo?
Heart, Lung and Circulation, Vol.29(4), pp.556-565
2020
Abstract
Hypertrophic cardiomyopathy (HCM) is the most common cardiovascular genetic disorder. While our mechanistic understanding has been informed by elegant gene discovery studies that led to the term "disease of the sarcomere", more recent investigations have challenged the single-gene hypothesis. Multimodality imaging has allowed better phenotyping to facilitate early diagnosis, identify treatable phenocopies, and guide management. While HCM remains an important cause of sudden death, recent studies have reported a substantial cumulative burden of heart failure and atrial fibrillation in middle-aged and older individuals. Nonetheless, improvements in risk stratification have allowed early intervention to transition HCM from being a common cause of sudden death in the young to a treatable chronic disease.
Details
- Title
- Hypertrophic Cardiomyopathy: Challenging the Status Quo?
- Authors
- John Younger (Author) - Royal Brisbane and Women's HospitalAda Lo (Author) - Royal Brisbane and Women's HospitalLouise McCormack (Author) - Royal Brisbane and Women's HospitalJulie McGaughran (Author) - Royal Brisbane and Women's HospitalSandhir Prasad (Author) - Royal Brisbane and Women's HospitalJohn J Atherton (Author) - University of the Sunshine Coast
- Publication details
- Heart, Lung and Circulation, Vol.29(4), pp.556-565
- Publisher
- Elsevier Australia
- Date published
- 2020
- DOI
- 10.1016/j.hlc.2019.12.005
- ISSN
- 1443-9506; 1443-9506
- Organisation Unit
- University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99451605102621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Cardiac & Cardiovascular Systems
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Source: InCites