Hyperosmotic Glucose Infusion During Hemorrhage Does Not Reduce Bacterial Translocation in 24 Hour-Starved Rats

C Nettelbladt; Mohammad Katouli; A Volpe; T Bark; B Heilborn; V Muratov; R Möllby; T Svenberg; O Ljungqvist

doi:10.1097/00024382-199508000-00006

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Hyperosmotic Glucose Infusion During Hemorrhage Does Not Reduce Bacterial Translocation in 24 Hour-Starved Rats

Journal article

Peer reviewed

Hyperosmotic Glucose Infusion During Hemorrhage Does Not Reduce Bacterial Translocation in 24 Hour-Starved Rats

C Nettelbladt, Mohammad Katouli, A Volpe, T Bark, B Heilborn, V Muratov, R Möllby, T Svenberg and O Ljungqvist

Shock, Vol.4(2), pp.113-116

1995

DOI: https://doi.org/10.1097/00024382-199508000-00006

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Abstract

Clinical Sciences

Food deprivation 24 h before stress increases bacterial translocation in hemorrhage. Presently it tested whether hyperosmolality, induced by exogenous glucose infusion to improve plasma refill, prevents or reduces bacterial translocation after experimental hemorrhage in 24 h food-deprived rats. Rats were given an i.v. infusion of either 2 mL of 30% glucose (G) or the same volume of .9% NaCl (C) while simultaneously being submitted to a standardized 60 min hemorrhage period, of moderate or more severe hemorrhage. Blood was not reinfused. Despite development of marked hyperglycemia resulting in significantly greater reductions in packed cell volume, bacterial translocation was detected similarly in both groups regardless of whether moderate (10/12-G, 9/12-C) or severe (15/19-G, 15/18-C) hemorrhage was inflicted. It was concluded that hyperglycemic hyperosmolality did not prevent bacterial translocation in these models of hemorrhagic stress in 24 h-starved rats.

Details

Title: Hyperosmotic Glucose Infusion During Hemorrhage Does Not Reduce Bacterial Translocation in 24 Hour-Starved Rats
Authors: C Nettelbladt (Author)
Mohammad Katouli (Author) - Karolinska Institute, Sweden
A Volpe (Author)
T Bark (Author)
B Heilborn (Author)
V Muratov (Author)
R Möllby (Author)
T Svenberg (Author)
O Ljungqvist (Author)
Publication details: Shock, Vol.4(2), pp.113-116
Publisher: Lippincott Williams & Wilkins
Date published: 1995
DOI: 10.1097/00024382-199508000-00006
ISSN: 1073-2322
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450048602621
Output Type: Journal article

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Web Of Science research areas: Critical Care Medicine; Hematology; Peripheral Vascular Disease; Surgery

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