Hydrogels as Emerging Materials for Translational Biomedicine

Kun Xue; Xiaoyuan Wang; Pei Wern Yong; David James Young; Yun-Long Wu; Zibiao Li; Xian Jun Loh

doi:10.1002/adtp.201800088

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Hydrogels as Emerging Materials for Translational Biomedicine

Journal article

Peer reviewed

Hydrogels as Emerging Materials for Translational Biomedicine

Kun Xue, Xiaoyuan Wang, Pei Wern Yong, David James Young, Yun-Long Wu, Zibiao Li and Xian Jun Loh

Advanced Therapeutics, Vol.2(1), 1800088

2019

DOI: https://doi.org/10.1002/adtp.201800088

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Abstract

Other Chemical Sciences

Hydrogels have been extensively investigated as biomaterials because of their excellent biocompatibility, and recent developments such as 3D printing and the incorporation of dynamic crosslinks have advanced the field considerably. However, the next step of in vivo translational biomedicine requires an understanding of essential hydrogel properties so that they can be designed to overcome the challenges of the living environment. In this review, the stringent design criteria required for in vivo applications are highlighted and recent advances in the repair of organ tissues (heart, bone, eye, etc.) and the therapeutic delivery of bioactive molecules are described. Commercially available hydrogel systems that can be used for translational biomedicine are also discussed, as is the long and sometimes fraught journey from the laboratory to the clinic.

Details

Title: Hydrogels as Emerging Materials for Translational Biomedicine
Authors: Kun Xue (Author) - Institute of Materials Research and Engineering, Singapore
Xiaoyuan Wang (Author) - Xiamen University, China
Pei Wern Yong (Author) - National University of Singapore, Singapore
David James Young (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Yun-Long Wu (Corresponding Author) - Xiamen University, China
Zibiao Li (Corresponding Author) - Institute of Materials Research and Engineering, Agency for Science, Singapore
Xian Jun Loh (Corresponding Author) - Institute of Materials Research and Engineering, Agency for Science, Singapore
Publication details: Advanced Therapeutics, Vol.2(1), 1800088
Publisher: John Wiley & Sons Ltd.
Date published: 2019
DOI: 10.1002/adtp.201800088
ISSN: 2366-3987; 2366-3987
Organisation Unit: University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99451407402621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Pharmacology & Pharmacy