Journal article
Human papillomavirus infection among head and neck squamous cell carcinomas in Southern China
PLoS One, Vol.14(9), e0221045
2019
Abstract
Human papillomavirus (HPV) related tumours account for a significant proportion of head and neck squamous cell carcinomas (HNSCCs) in developed countries. They respond better to chemo- and radio-therapy, and have a better stage specific prognosis. To establish their prevalence in China, we assessed a series of histology confirmed HNSCCs collected in Zhejiang and Guangdong provinces by PCR for HPV DNA and by immunohistochemistry for p16 protein status. Among 303 HNSCCs, HPV DNA was detected in 26.4%, with HPV16 DNA in 71% of these. Of HNSCC located in the oropharynx, 38.55% (32/83) were HPV+ve. In this series, p16 status was a relatively poor predictor of HPV status as detected by PCR. The stage specific survival time of HPV+ HNSCCs was significantly longer than for HPV- HNSCC. HPV status should be assessed for oropharyngeal cancers in China to assist with appropriate management, and prophylaxis against HPV infection should be considered to reduce the incidence of this disease.
Details
- Title
- Human papillomavirus infection among head and neck squamous cell carcinomas in Southern China
- Authors
- Guoying Ni (Author) - University of the Sunshine CoastKunsong Huang (Author) - Guangdong Pharmaceutical University, ChinaYi Luan (Author) - Foshan First People's Hospital, ChinaZaizai Cao (Author) - Wenzhou Medical University, ChinaShu Chen (Author) - Foshan First People's Hospital, ChinaBowei Ma (Author) - Guangdong Pharmaceutical University, ChinaJianwei Yuan (Author) - Guangdong Pharmaceutical University, ChinaXiaolian Wu (Author) - Foshan First People's Hospital, ChinaGuoqiang Chen (Author) - Foshan First People's Hospital, ChinaTianfang Wang (Author) - University of the Sunshine CoastHejie Li (Author) - University of the Sunshine CoastShelley F Walton (Author) - University of the Sunshine CoastFang Liu (Author) - Foshan First People's Hospital, ChinaBobei Chen (Author) - Wenzhou Medical University, ChinaYuejian Wang (Author) - Foshan First People's Hospital, ChinaXuan Pan (Author) - Guangdong Pharmaceutical University, ChinaXiao Song Liu (Author) - University of the Sunshine CoastIan H Frazer (Author) - University of Queensland
- Publication details
- PLoS One, Vol.14(9), e0221045; 13
- Publisher
- Public Library of Science
- Date published
- 2019
- DOI
- 10.1371/journal.pone.0221045
- ISSN
- 1932-6203
- Copyright note
- Copyright © 2019 Ni et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99450778002621
- Output Type
- Journal article
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- Domestic collaboration
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- Oncology
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