Journal article
Human pancreatic islet transplantation: An update and description of the establishment of a pancreatic islet isolation laboratory
Archives of Endocrinology and Metabolism, Vol.59(2), pp.161-170
2015
Abstract
Type 1 diabetes mellitus (T1DM) is associated with chronic complications that lead to high morbidity and mortality rates in young adults of productive age. Intensive insulin therapy has been able to reduce the likelihood of the development of chronic diabetes complications. However, this treatment is still associated with an increased incidence of hypoglycemia. In patients with "brittle T1DM", who have severe hypoglycemia without adrenergic symptoms (hypoglycemia unawareness), islet transplantation may be a therapeutic option to restore both insulin secretion and hypoglycemic perception. The Edmonton group demonstrated that most patients who received islet infusions from more than one donor and were treated with steroid-free immunosuppressive drugs displayed a considerable decline in the initial insulin independence rates at eight years following the transplantation, but showed permanent C-peptide secretion, which facilitated glycemic control and protected patients against hypoglycemic episodes. Recently, data published by the Collaborative Islet Transplant Registry (CITR) has revealed that approximately 50% of the patients who undergo islet transplantation are insulin independent after a 3-year follow-up. Therefore, islet transplantation is able to successfully decrease plasma glucose and HbA1c levels, the occurrence of severe hypoglycemia, and improve patient quality of life. The goal of this paper was to review the human islet isolation and transplantation processes, and to describe the establishment of a human islet isolation laboratory at the Endocrine Division of the Hospital de ClÃnicas de Porto Alegre - Rio Grande do Sul, Brazil.
Details
- Title
- Human pancreatic islet transplantation: An update and description of the establishment of a pancreatic islet isolation laboratory
- Authors
- J Rheinheimer (Author) - Hospital de Clinicas de Porto Alegre (HCPA), BrazilA C Bauer (Author) - Hospital de Clinicas de Porto Alegre (HCPA), BrazilS P Silveiro (Author) - Hospital de Clinicas de Porto Alegre (HCPA), BrazilA A F Estivalet (Author) - Hospital de Clinicas de Porto Alegre (HCPA), BrazilA P Bouças (Author) - Hospital de Clinicas de Porto Alegre (HCPA), BrazilA R Rosa (Author) - Hospital de Clinicas de Porto Alegre (HCPA), BrazilB M de Souza (Author) - Hospital de Clinicas de Porto Alegre (HCPA), BrazilF S de Oliveira (Author) - Hospital de Clinicas de Porto Alegre (HCPA), BrazilL A Cruz (Author) - Hospital de Clinicas de Porto Alegre (HCPA), BrazilL A Brondani (Author) - Hospital de Clinicas de Porto Alegre (HCPA), BrazilM J Azevedo (Author) - Universidade Federal do Rio Grande do Sul (UFRGS), BrazilN E Lemos (Author) - Hospital de Clinicas de Porto Alegre (HCPA), BrazilR Carlessi (Author) - Hospital de Clinicas de Porto Alegre (HCPA), BrazilT S Assmann (Author) - Hospital de Clinicas de Porto Alegre (HCPA), BrazilJ L Gross (Author) - Hospital de Clinicas de Porto Alegre (HCPA), BrazilC B Leitão (Author) - Hospital de Clinicas de Porto Alegre (HCPA), BrazilD Crispim (Author) - Hospital de Clinicas de Porto Alegre (HCPA), Brazil
- Publication details
- Archives of Endocrinology and Metabolism, Vol.59(2), pp.161-170
- Publisher
- Sociedade Brasileira de Endocrinologia e Metabologia
- Date published
- 2015
- DOI
- 10.1590/2359-3997000000030
- ISSN
- 2359-3997
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99451209602621
- Output Type
- Journal article
Metrics
58 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Web Of Science research areas
- Endocrinology & Metabolism
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites