Journal article
Human neutrophil antigen-4a gene frequencies in an Australian population, determined by a new polymerase chain reaction method using sequence-specific primers
Transfusion Medicine, Vol.13(3), pp.149-152
2003
Abstract
Human neutrophil antigen-4a (HNA-4a) is a high-frequency (99% in the USA) neutrophil antigen, which has recently been linked to a case of alloimmune neonatal neutropenia. We have devised a new polymerase chain reaction sequence-specific primer (PCR-SSP) method to assess HNA-4a genotype, and used it to determine the HNA-4a gene frequencies in an Australian population. The gene frequency was found to be 0.906, which is the same as in the American population. The PCR-SSP genotyping method perfectly correlates with serological phenotyping and is efficient for screening large numbers of samples.
Details
- Title
- Human neutrophil antigen-4a gene frequencies in an Australian population, determined by a new polymerase chain reaction method using sequence-specific primers
- Authors
- H D Clague (Author) - Australian Red Cross Blood ServiceYoke Lin Fung (Author) - Australian Red Cross Blood ServiceR M Minchinton (Author) - Australian Red Cross Blood Service
- Publication details
- Transfusion Medicine, Vol.13(3), pp.149-152
- Publisher
- Wiley-Blackwell Publishing Ltd.
- Date published
- 2003
- DOI
- 10.1046/j.1365-3148.2003.00435.x
- ISSN
- 0958-7578
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99449118102621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Hematology
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Source: InCites