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Published VersionCC BY V4.0, Open Access
Journal article
Human Herpesvirus 8 in Australia: DNAemia and Cumulative Exposure in Blood Donors
Viruses, Vol.14(10), pp.1-8
2022
Abstract
Human herpesvirus 8 (HHV‐8), the causative agent of Kaposi's sarcoma, multicentric Cas‐ tleman's disease and primary effusion lymphoma, predominantly manifests in immunocompro‐ mised individuals. However, infection in immunocompetent individuals does occur. The preva‐ lence of HHV‐8 exposure in blood donors from non‐endemic countries ranges between 1.2% and 7.3%. Nothing was known about the prevalence in Australian blood donors. Therefore, this study investigated the active and cumulative exposure of HHV‐8 in this cohort. Plasma samples (n = 480) were collected from eastern Australian blood donors and were tested for HHV‐8 DNA by qPCR, and for HHV‐8 antibodies by two different ELISAs. Samples initially positive on either ELISA were retested in duplicate on both, and on a mock‐coated ELISA. Any samples positive two or three out of the three times tested on at least one ELISA, and repeat negative on the mock‐coated ELISA, were assigned as repeat positive. None of the 480 samples tested contained HHV‐8 DNA. Serological testing revealed 28 samples (5.83%; 95% CI: 3.74−7.93%) had antibodies to HHV‐8. There was no difference (p > 0.05) in seropositivity between sex or with increasing age. This is the first study to show serological evidence of cumulative HHV‐8 exposure and no HHV‐8 DNAemia within a select blood donor population in Australia. Our molecular and serological data is consistent with pub‐ lished results for blood donors residing in HHV‐8 non‐endemic countries, which shows the preva‐ lence to be very low.
Details
- Title
- Human Herpesvirus 8 in Australia: DNAemia and Cumulative Exposure in Blood Donors
- Authors
- David Speicher (Corresponding Author) - Griffith UniversityJesse J Fryk (Author) - Australian Red Cross Blood ServiceVictoria Kashchuk (Author) - Griffith UniversityHelen Faddy (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - LegacyNewell W Johnson (Author) - Griffith University
- Publication details
- Viruses, Vol.14(10), pp.1-8
- Publisher
- MDPI AG
- Date published
- 2022
- DOI
- 10.3390/v14102185
- ISSN
- 1999-4915
- Copyright note
- © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99680498402621
- Output Type
- Journal article
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