Host immune responses to the itch mite, Sarcoptes scabiei, in humans

Sajad A Bhat; Kate E Mounsey; Xiao Song Liu; Shelley F Walton

doi:10.1186/s13071-017-2320-4

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Host immune responses to the itch mite, Sarcoptes scabiei, in humans

Journal article

Open access

Peer reviewed

Host immune responses to the itch mite, Sarcoptes scabiei, in humans

Sajad A Bhat, Kate E Mounsey, Xiao Song Liu and Shelley F Walton

Parasites & vectors, Vol.10, 385

2017

DOI: https://doi.org/10.1186/s13071-017-2320-4

PMCID: PMC5553898

PMID: 28797273

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Abstract

sarcoptes scabiei

scabies

crusted scabies

immune responses

cytokines

Scabies is a parasitic disease due to infestation of skin by the burrowing mite Sarcoptes scabiei. Scabies is a major public health problem and endemic in resource poor communities worldwide affecting over 100 million people. Associated bacterial infections cause substantial morbidity, and in severe cases can lead to renal and cardiac diseases. Mite infestation of the skin causes localised cutaneous inflammation, pruritus, skin lesions, and allergic and inflammatory responses are mounted by the host against the mite and its products. Our current understanding of the immune and inflammatory responses associated with the clinical manifestations in scabies is far outweighed by the significant global impact of the disease. This review aims to provide a better understanding of human immune responses to S. scabiei in ordinary and crusted scabies phenotypes.

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Title: Host immune responses to the itch mite, Sarcoptes scabiei, in humans
Authors: Sajad A Bhat (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Kate E Mounsey (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Xiao Song Liu (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Shelley F Walton (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Publication details: Parasites & vectors, Vol.10, 385; 12
Publisher: BioMed Central Ltd.
Date published: 2017
DOI: 10.1186/s13071-017-2320-4
ISSN: 1756-3305
PMID: 28797273; PMC5553898
Copyright note: Copyright © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Organisation Unit: School of Health - Biomedicine; GeneCology Research Centre - Legacy; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99450537702621
Output Type: Journal article

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