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Int J of Food Sci Tech - 2023 - Wong - Holothuria scabra Jaegar 1833 Sandfish extracts and collagens modulate690.22 kB
Published VersionCC BY-NC V4.0, Open Access
Journal article
Holothuria scabra Jaegar 1833 (Sandfish) extracts and collagens modulate protein-bound Nε-carboxymethyllysine, Nε-carboxyethyllysine and methylglyoxal-derived hydroimidazolone-1 levels
International Journal of Food Science & Technology, Vol.58(4), pp.1962-1969
2023
Abstract
In this study, sea cucumber (Holothuria scabra; Jaegar 1833) extracts and collagens were evaluated for inhibitory properties of protein-bound advanced glycation end products (AGEs). Processed dried sea cucumber with salt extract showed a significant lower IC50 value for fluorescent AGEs (9.19 ± 7.68 μg mL−1, P < 0.05) and fructosamine (503.47 ± 46.37 μg mL−1, P < 0.05), respectively. Processed dried with and without salt extracts significantly reduced the Nε-carboxymethyllysine (CML) and methylglyoxal-derived hydroimidazolone-1 (MG-H1) levels tested at 250 μg mL−1. Smoked dried and fresh-dried extracts significantly reduced the Nε-carboxyethyllysine (CEL) levels tested at 250 μg mL−1. Pepsin-solubilised collagen and the crude collagen fibrils significantly reduced CML and MG-H1 levels whereas CEL levels were unchanged. Pearson's correlation analysis showed that protein-bound AGE and CML inhibition significantly correlated with the total phenolic and antioxidant activities, respectively. This study provides a strong rationale for further investigation aimed at identifying the active compounds responsible for the observed effects on biomarkers relevant to diabetes.
Details
- Title
- Holothuria scabra Jaegar 1833 (Sandfish) extracts and collagens modulate protein-bound Nε-carboxymethyllysine, Nε-carboxyethyllysine and methylglyoxal-derived hydroimidazolone-1 levels
- Authors
- Hoi Y. Wong (Author) - University of South AustraliaEmma L. Jaunay (Author) - University of South AustraliaWai C. D. Lau (Author) - University of South AustraliaBrock Peake (Author) - University of South AustraliaRavinesh Ram (Author) - Fiji National UniversityPaul Southgate (Author) - University of the Sunshine Coast, Queensland, Australian Centre for Pacific Islands ResearchPermal Deo (Corresponding Author) - University of South Australia
- Publication details
- International Journal of Food Science & Technology, Vol.58(4), pp.1962-1969
- Publisher
- Wiley-Blackwell Publishing Ltd.
- Date published
- 2023
- DOI
- 10.1111/ijfs.16341
- ISSN
- 1365-2621; 0950-5423
- Copyright note
- © 2023 The Authors. International Journal of Food Science & Technology published by John Wiley & Sons Ltd on behalf of Institute of Food, Science and Technology (IFSTTF). This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
- Organisation Unit
- Australian Centre for Pacific Islands Research; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 99706998102621
- Output Type
- Journal article
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