Journal article
Hippocampal subfield volumes predict treatment response to oral ketamine in people with suicidality
Journal of Psychiatric Research, Vol.169, pp.192-200
2024
Abstract
Ongoing stress results in hippocampal neuro-structural alterations which produce pathological consequences, including depression and suicidality. Ketamine may ameliorate stress related illnesses, including suicidality, via neuroplasticity processes. This novel study sought to determine whether oral ketamine treatment specifically affects hippocampal (whole and subfield) volumes in patients with chronic suicidality and MDD. It was hypothesised that oral ketamine treatment would differentially alter hippocampal volumes in trial participants categorised as ketamine responders, versus those who were non-responders. Twenty-eight participants received 6 single, weekly doses of oral ketamine (0.5–3 mg/kg) and underwent MRI scans at pre-ketamine (week 0), post-ketamine (week 6), and follow up (week 10). Hippocampal subfield volumes were extracted using the longitudinal pipeline in FreeSurfer. Participants were grouped according to ketamine response status and then compared in terms of grey matter volume (GMV) changes, among 10 hippocampal regions, over 6 and 10 weeks. Mixed ANOVAs were used to analyse interactions between time and group. Post treatment analysis revealed a significant main effect of group for three left hippocampal GMVs as well in the left and right whole hippocampus. Ketamine acute responders (Week 6) showed increased GMVs in both left and right whole hippocampus and in three subfields compared to acute non-responders, across all three timepoints, suggesting that pre-treatment increased hippocampal GMVs (particularly left hemisphere) may be predictive biomarkers of acute treatment response. Future studies should further investigate the potential of hippocampal volumes as a biomarker of ketamine treatment response..
Details
- Title
- Hippocampal subfield volumes predict treatment response to oral ketamine in people with suicidality
- Authors
- Megan Dutton (Corresponding Author) - University of the Sunshine Coast, Queensland, Thompson InstituteAmanda Boyes (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteAdem T Can (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteAbdalla Z Mohamed (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteMaryam Hajishafiee (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteZack Y Shan (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteJim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteDaniel F Hermens (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
- Publication details
- Journal of Psychiatric Research, Vol.169, pp.192-200
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.jpsychires.2023.11.040
- ISSN
- 1879-1379
- Grant note
- This study was funded by a grant from the Australian Commonwealth Government’s ‘Prioritizing Mental Health Initiative’ (2018–2019).
- Organisation Unit
- Thompson Institute
- Language
- English
- Record Identifier
- 99982898302621
- Output Type
- Journal article
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- Psychiatry
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