Journal article
Hippocampal glutamatergic/NMDA receptor functioning in bipolar disorder: A study combining mismatch negativity and proton magnetic resonance spectroscopy
Psychiatry Research: Neuroimaging, Vol.233(2), pp.88-94
2015
Abstract
Disturbances in the hippocampal glutamate (Glu)/N-methyl-d-aspartate (NMDA) system have been implicated in the pathophysiology of bipolar disorder (BD). Here we aim to provide a targeted integration of two measures of glutamatergic functioning in BD; the association between mismatch negativity (MMN) and in vivo hippocampal-Glu measured via proton magnetic resonance spectroscopy (1H MRS). Participants comprised of 33 patients with BD and 23 matched controls who underwent a two-tone passive, duration deviant MMN paradigm and 1H MRS. Levels of Glu/creatine (Cr) in the hippocampus were determined. Pearson[U+05F3]s correlations were used to determine associations between MMN and Glu/Cr. In controls, MMN amplitude was positively associated with Glu/Cr at the left temporal site. We did not find any significant associations with Glu/Cr and frontocentral MMN nor did we find any significant associations in BD patients. The results provide further insight into the neurophysiology of MMN, with evidence supporting the role of hippocampal-Glu signalling through the NMDA receptor in temporal MMN. Our data also demonstrate that Glu/Cr regulation of MMN is dampened in BD, which may indicate a lack of tightly regulated hippocampal NMDA functioning. These findings provide insight into the underlying basis of glutamatergic transmission disturbances implicated in the disorder. © 2015 Elsevier Ireland Ltd.
Details
- Title
- Hippocampal glutamatergic/NMDA receptor functioning in bipolar disorder: A study combining mismatch negativity and proton magnetic resonance spectroscopy
- Authors
- K M Chitty (Author) - University of SydneyJim Lagopoulos (Author) - University of SydneyI B Hickie (Author) - University of SydneyDaniel F Hermens (Author) - University of Sydney
- Publication details
- Psychiatry Research: Neuroimaging, Vol.233(2), pp.88-94
- Publisher
- Elsevier Ireland Ltd.
- Date published
- 2015
- DOI
- 10.1016/j.pscychresns.2015.05.002
- ISSN
- 0925-4927
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99449494202621
- Output Type
- Journal article
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- Web Of Science research areas
- Clinical Neurology
- Neuroimaging
- Psychiatry
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Source: InCites