Hippocampal development in youth with a history of childhood maltreatment

Casey Paquola; Maxwell Bennett; Sean N Hatton; Daniel F Hermens; Inge Groote; Jim Lagopoulos

doi:10.1016/j.jpsychires.2017.03.019

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Hippocampal development in youth with a history of childhood maltreatment

Journal article

Peer reviewed

Hippocampal development in youth with a history of childhood maltreatment

Casey Paquola, Maxwell Bennett, Sean N Hatton, Daniel F Hermens, Inge Groote and Jim Lagopoulos

Journal of Psychiatric Research, Vol.91, pp.149-155

2017

DOI: https://doi.org/10.1016/j.jpsychires.2017.03.019

Appears in UniSC Diversity and Inclusion Research Collection

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Abstract

childhood maltreatment

MRI

hippocampus

amygdala

development

stress

UniSC Diversity Area - Life Stages

Childhood maltreatment (CM) is associated with enhanced risk of psychiatric illness and reduced subcortical grey matter in adulthood. The hippocampus and amygdala, due to their involvement in stress and emotion circuitries, have been subject to extensive investigations regarding the effect of CM. However, the complex relationship between CM, subcortical grey matter and mental illness remains poorly understood partially due to a lack of longitudinal studies. Here we used segmentation and linear mixed effect modelling to examine the impact of CM on hippocampal and amygdala development in young people with emerging mental illness. A total of 215 structural magnetic resonance imaging (MRI) scans were acquired from 123 individuals (age: 14-28 years, 79 female), 52 of whom were scanned twice or more. Hippocampal and amygdala volumes increased linearly with age, and their developmental trajectories were not moderated by symptom severity. However, exposure to CM was associated with significantly stunted right hippocampal growth. This finding bridges the gap between child and adult research in the field and provides novel evidence that CM is associated with disrupted hippocampal development in youth. Although CM was associated with worse symptom severity, we did not find evidence that CM-induced structural abnormalities directly underpin psychopathology. This study has important implications for the psychiatric treatment of individuals with CM since they are clinically and neurobiologically distinct from their peers who were not maltreated.

Details

Title: Hippocampal development in youth with a history of childhood maltreatment
Authors: Casey Paquola (Author) - University of Sydney
Maxwell Bennett (Author) - University of Sydney
Sean N Hatton (Author) - University of Sydney
Daniel F Hermens (Author) - University of Sydney
Inge Groote (Author) - University of Oslo, Norway
Jim Lagopoulos (Author) - University of the Sunshine Coast - Faculty of Arts, Business and Law
Publication details: Journal of Psychiatric Research, Vol.91, pp.149-155
Publisher: Pergamon
Date published: 2017
DOI: 10.1016/j.jpsychires.2017.03.019
ISSN: 0022-3956
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99451279002621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Psychiatry

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