Journal article
Hijacking of GABAA Receptors by Mutant Glycine Receptors
Trends in Molecular Medicine, Vol.25(10), pp.823-825
2019
Abstract
Startle disease results from mutations in genes encoding inhibitory GlyR α1 and β subunits or the presynaptic glycine transporter GlyT2. However, the most effective therapies are benzodiazepines that potentiate inhibitory GABAAR function. A recent publication by Zou et al. adds further complexity by suggesting that dominant GlyR α1 mutants assemble into pre- and extrasynaptic GABAARs.
Details
- Title
- Hijacking of GABAA Receptors by Mutant Glycine Receptors
- Authors
- Robert J Harvey (Author) - University of the Sunshine Coast
- Publication details
- Trends in Molecular Medicine, Vol.25(10), pp.823-825
- Publisher
- Elsevier Ltd.
- DOI
- 10.1016/j.molmed.2019.08.010
- ISSN
- 1471-4914; 1471-499X
- Organisation Unit
- School of Health and Behavioural Sciences - Legacy; School of Health and Sport Sciences - Legacy; University of the Sunshine Coast, Queensland; Centre for Bioinnovation; School of Health
- Language
- English
- Record Identifier
- 99450766102621
- Output Type
- Journal article
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- Biochemistry & Molecular Biology
- Cell Biology
- Medicine, Research & Experimental
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Source: InCites