Journal article
Highly effective SNP-based association mapping and management of recessive defects in livestock
Nature Genetics, Vol.40(4), pp.449-454
2008
Abstract
The widespread use of elite sires by means of artificial insemination in livestock breeding leads to the frequent emergence of recessive genetic defects, which cause significant economic and animal welfare concerns. Here we show that the availability of genome-wide, high-density SNP panels, combined with the typical structure of livestock populations, markedly accelerates the positional identification of genes and mutations that cause inherited defects. We report the fine-scale mapping of five recessive disorders in cattle and the molecular basis for three of these: congenital muscular dystony (CMD) types 1 and 2 in Belgian Blue cattle and ichthyosis fetalis in Italian Chianina cattle. Identification of these causative mutations has an immediate translation into breeding practice, allowing marker assisted selection against the defects through avoidance of at-risk matings. © 2008 Nature Publishing Group.
Details
- Title
- Highly effective SNP-based association mapping and management of recessive defects in livestock
- Authors
- C Charlier (Author) - University of Liege, BelgiumW Coppieters (Author) - University of Liege, BelgiumF Rollin (Author) - University of Liege, BelgiumD Desmecht (Author) - University of Liege, BelgiumJ S Agerholm (Author) - University of Copenhagen, DenmarkN Cambisano (Author) - University of Liege, BelgiumE Carta (Author) - University College London, United KingdomS Dardano (Author) - University of Milan, ItalyM Dive (Author)C Fasquelle (Author) - University of Liege, BelgiumJ C Frennet (Author)R Hanset (Author) - University of Liege, BelgiumX Hubin (Author) - Association Wallonne de l'Elevage, BelgiumC Jorgensen (Author) - University of Copenhagen, DenmarkL Karim (Author) - University of Liege, BelgiumM Kent (Author) - Norwegian University of Life Sciences, NorwayK Harvey (Author) - University College London, United KingdomB R Pearce (Author) - University College London, United KingdomP Simon (Author) - University of Liege, BelgiumN Tama (Author) - University of Liege, BelgiumH Nie (Author) - University of Liege, BelgiumS Vandeputte (Author) - University of Liege, BelgiumS Lien (Author) - Norwegian University of Life Sciences, NorwayM Longeri (Author) - University of Milan, ItalyM Fredholm (Author) - University of Copenhagen, DenmarkRobert J Harvey (Author) - University College London, United KingdomM Georges (Author) - University of Liege, Belgium
- Publication details
- Nature Genetics, Vol.40(4), pp.449-454
- Publisher
- Nature Publishing Group
- DOI
- 10.1038/ng.96
- ISSN
- 1061-4036
- Organisation Unit
- Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy; School of Health and Sport Sciences - Legacy; University of the Sunshine Coast, Queensland; School of Health
- Language
- English
- Record Identifier
- 99450684102621
- Output Type
- Journal article