Journal article
Higher intensity of purifying selection on >90% of the human genes revealed by the intrinsic replacement mutation rates
Molecular Biology and Evolution, Vol.23(12), pp.2283-2287
2006
Abstract
For over 3 decades, the rate of replacement mutations has been assumed to be equal to, and estimated from, the rate of "strictly" neutral sequence divergence in noncoding regions and in silent-codon positions where mutations do not alter the amino acid encoded. This assumption is fundamental to estimating the fraction of harmful protein mutations and to identifying adaptive evolution at individual codons and proteins. We show that the assumption is not justifiable because a much larger fraction of codon positions is involved in hypermutable CpG dinucleotides as compared with the introns, leading to a higher expected replacement mutation rate per site in a vast majority of the genes. Consideration of this difference reveals a higher intensity of purifying natural selection than previously inferred in human genes. We also show that a much smaller number of genes are expected to be evolving with positive selection than that predicted using sequence divergence at intron and silent positions in the human genome. These patterns indicate the need for using new approaches for estimating rates of amino acid-altering mutations in order to find positively selected genes and codons in genomes that contain hypermutable CpG's. © The Author 2006. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved.
Details
- Title
- Higher intensity of purifying selection on >90% of the human genes revealed by the intrinsic replacement mutation rates
- Authors
- Sankar Subramanian (Author) - Arizona State University, United StatesS Kumar (Author) - Arizona State University, United States
- Publication details
- Molecular Biology and Evolution, Vol.23(12), pp.2283-2287
- Publisher
- Oxford University Press
- Date published
- 2006
- DOI
- 10.1093/molbev/msl123
- ISSN
- 0737-4038
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99450547302621
- Output Type
- Journal article
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