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High-throughput immunogenetic typing of koalas suggests possible link between MHC alleles and cancers1.85 MB
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Journal article
High-throughput immunogenetic typing of koalas suggests possible link between MHC alleles and cancers
Immunogenetics, Vol.72(9-10), pp.499-506
2020
PMID: 33083849
Abstract
Characterizing the allelic diversity within major histocompatibility complex (MHC) genes is an important way of determining the potential genetic resilience of a population to infectious and ecological pressures. For the koala (Phascolarctos cinereus), endemic diseases, anthropogenic factors and climate change are all placing increased pressure on this vulnerable marsupial. To increase the ability of researchers to study MHC genetics in koalas, this study developed and tested a high-throughput immunogenetic profiling methodology for targeting MHC class I UA and UC genes and MHC class II DAB, DBB, DCB and DMB genes in a population of 82 captive koalas. This approach was validated by comparing the determined allelic profiles from 36 koala family units (18 dam-sire-joey units and 18 parent-joey pairs), finding 96% overall congruence within family profiles. Cancers are a significant cause of morbidity in koalas and the risk factors remain undetermined. Our analysis of this captive population revealed several novel MHC alleles, including a potential link between the DBB*03 allele and a risk of developing cancer. This method offers a reliable, high-throughput protocol for expanded study into koala immunogenetics.
Details
- Title
- High-throughput immunogenetic typing of koalas suggests possible link between MHC alleles and cancers
- Authors
- Bonnie Quigley (Corresponding Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - LegacyGalit Tzipori (Author) - Lone Pine Koala SanctuaryK Nilsson (Author) - Lone Pine Koala SanctuaryPeter Timms (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - Legacy
- Publication details
- Immunogenetics, Vol.72(9-10), pp.499-506
- Publisher
- Springer
- Date published
- 2020
- DOI
- 10.1007/s00251-020-01181-7
- ISSN
- 1432-1211; 0093-7711
- PMID
- 33083849
- Copyright note
- Copyright (c) 2020 The Author. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99482289502621
- Output Type
- Journal article
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- Genetics & Heredity
- Immunology
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