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Published VersionCC BY V4.0, Open Access
Journal article
High sampling resolution optical coherence tomography reveals potential concurrent reductions in ganglion cell-inner plexiform and inner nuclear layer thickness but not in outer retinal thickness in glaucoma
Ophthalmic and Physiological Optics, Vol.43(1), pp.46-63
2023
PMID: 36416369
Abstract
Purpose:
To analyse optical coherence tomography (OCT)-derived inner nuclear layer (INL) and outer retinal complex (ORC) measurements relative to ganglion cell-inner plexiform layer (GCIPL) measurements in glaucoma.
Methods:
Glaucoma participants (n = 271) were categorised by 10-2 visual field defect type. Differences in GCIPL, INL and ORC thickness were calculated between glaucoma and matched healthy eyes (n = 548). Hierarchical cluster algorithms were applied to generate topographic patterns of retinal thickness change, with agreement between layers assessed using Cohen's kappa (κ). Differences in GCIPL, INL and ORC thickness within and outside GCIPL regions showing the greatest reductions and Spearman's correlations between layer pairs were compared with 10-2 mean deviation (MD) and pattern standard deviation (PSD) to determine trends with glaucoma severity.
Results:
Glaucoma participants with inferior and superior defects presented with concordant GCIPL and INL defects demonstrating mostly fair-to-moderate agreement (κ = 0.145–0.540), which was not observed in eyes with no or ring defects (κ = −0.067–0.230). Correlations (r) with MD and PSD were moderate and weak in GCIPL and INL thickness differences, respectively (GCIPL vs. MD r = 0.479, GCIPL vs. PSD r = −0.583, INL vs. MD r = 0.259, INL vs. PSD r = −0.187, p = <0.0001–0.002), and weak in GCIPL-INL correlations (MD r = 0.175, p = 0.004 and PSD r = 0.154, p = 0.01). No consistent patterns in ORC thickness or correlations were observed.
Conclusions:
In glaucoma, concordant reductions in macular INL and GCIPL thickness can be observed, but reductions in ORC thickness appear unlikely. These findings suggest that trans-synaptic retrograde degeneration may occur in glaucoma and could indicate the usefulness of INL thickness in evaluating glaucomatous damage.
Details
- Title
- High sampling resolution optical coherence tomography reveals potential concurrent reductions in ganglion cell-inner plexiform and inner nuclear layer thickness but not in outer retinal thickness in glaucoma
- Authors
- Janelle Tong (Author) - UNSW SydneyJack Phu (Author) - UNSW SydneyDavid Alonso-Caneiro (Author) - Queensland University of TechnologySieu K. Khuu (Author) - UNSW SydneyMichael Kalloniatis (Corresponding Author) - UNSW Sydney
- Publication details
- Ophthalmic and Physiological Optics, Vol.43(1), pp.46-63
- Publisher
- Wiley-Blackwell Publishing Ltd.
- Date published
- 2023
- DOI
- 10.1111/opo.13065
- ISSN
- 1475-1313; 0275-5408
- PMID
- 36416369
- Copyright note
- © 2022 The Authors. Ophthalmic and Physiological Optics published by John Wiley & Sons Ltd on behalf of College of Optometrists. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Grant note
- National Health and Medical Research Council of Australia Ideas Grant [NHMRC 1186915].
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 99973598102621
- Output Type
- Journal article
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