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Journal article
High-resolution two-photon polymerization: the most versatile technique for the fabrication of microneedle arrays
Microsystems & Nanoengineering, Vol.7, pp.1-17
2021
PMID: 34567783
Abstract
Microneedle patches have received much interest in the last two decades as drug/vaccine delivery or fluid sampling systems for diagnostic and monitoring purposes. Microneedles are manufactured using a variety of additive and subtractive micromanufacturing techniques. In the last decade, much attention has been paid to using additive manufacturing techniques in both research and industry, such as 3D printing, fused deposition modeling, inkjet printing, and two-photon polymerization (2PP), with 2PP being the most flexible method for the fabrication of microneedle arrays. 2PP is one of the most versatile and precise additive manufacturing processes, which enables the fabrication of arbitrary three-dimensional (3D) prototypes directly from computer-aided-design (CAD) models with a resolution down to 100 nm. Due to its unprecedented flexibility and high spatial resolution, the use of this technology has been widespread for the fabrication of bio-microdevices and bio-nanodevices such as microneedles and microfluidic devices. This is a pioneering transformative technology that facilitates the fabrication of complex miniaturized structures that cannot be fabricated with established multistep manufacturing methods such as injection molding, photolithography, and etching. Thus, microstructures are designed according to structural and fluid dynamics considerations rather than the manufacturing constraints imposed by methods such as machining or etching processes. This article presents the fundamentals of 2PP and the recent development of microneedle array fabrication through 2PP as a precise and unique method for the manufacture of microstructures, which may overcome the shortcomings of conventional manufacturing processes.
Details
- Title
- High-resolution two-photon polymerization: the most versatile technique for the fabrication of microneedle arrays
- Authors
- Zahra Faraji Rad (Corresponding Author) - University of Southern QueenslandPhilip D. Prewett - University of BirminghamGraham J. Davies - UNSW Sydney
- Publication details
- Microsystems & Nanoengineering, Vol.7, pp.1-17
- Publisher
- Nature Publishing Group
- Date published
- 2021
- DOI
- 10.1038/s41378-021-00298-3
- ISSN
- 2055-7434
- PMID
- 34567783
- Copyright note
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third-party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 991140305702621
- Output Type
- Journal article
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