High levels of mannose-binding lectin are associated with poor outcomes after lung transplantation

Katherine E Carroll; Melinda M Dean; Susan L Heatley; Aislin C Meehan; Nicole A Misfud; Tom C Kotsimbos; Greg I Snell; Glen P Westall

doi:10.1097/TP.0b013e318212c7d6

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High levels of mannose-binding lectin are associated with poor outcomes after lung transplantation

Journal article

Peer reviewed

High levels of mannose-binding lectin are associated with poor outcomes after lung transplantation

Katherine E Carroll, Melinda M Dean, Susan L Heatley, Aislin C Meehan, Nicole A Misfud, Tom C Kotsimbos, Greg I Snell and Glen P Westall

Transplantation, Vol.91(9), pp.1044-1049

2011

DOI: https://doi.org/10.1097/TP.0b013e318212c7d6

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Abstract

lung transplantation

complement

mannose-binding lectin

genotype

bronchiolitis obliterans syndrome

Background. Mannose-binding lectin (MBL) is a key molecule of the innate immune system and, in addition to the classical and alternative pathways, a principle driver of complement activation. Genetic mutations of MBL are common, result in low serum levels of MBL, and are associated with increased infection risk in solid-organ transplant recipients. Methods. We performed a retrospective study of MBL2 genotype and plasma and bronchoalveolar lavage (BAL) MBL levels in 37 lung transplant recipients (LTR). Plasma MBL levels were measured pretransplant and both plasma and BAL MBL levels were measured at 3, 6, and 12 months after lung transplantation. MBL2 genotyping was performed on recipient and donor peripheral blood mononuclear cells. Clinical variables analyzed included primary graft dysfunction, intensive care unit stay, acute allograft rejection, infection, bronchiolitis obliterans syndrome (BOS), and mortality. Results. Plasma MBL levels posttransplant were predicted by recipient, and not donor MBL2 genotype. Compared with pretransplant levels, plasma MBL was significantly increased at 3, 6, and 12 months posttransplant (P<0.05). LTR who developed BOS or died during the study period had higher plasma MBL levels at 6 and 12 months posttransplant (P≤0.05) compared with LTR with stable graft function. MBL was not routinely detected in the lung allograft; however if present in the BAL at 3 and 6 months posttransplant, it was associated with the later development of BOS (P<0.05). Conclusions. Plasma MBL levels increase after lung transplantation and persistently increased MBL levels are associated with poor long-term outcomes.

Details

Title: High levels of mannose-binding lectin are associated with poor outcomes after lung transplantation
Authors: Katherine E Carroll (Author) - St Vincent's Hospital Melbourne
Melinda M Dean (Author) - Australian Red Cross Blood Service
Susan L Heatley (Author) - Australian Red Cross Blood Service
Aislin C Meehan (Author) - Monash University
Nicole A Misfud (Author) - Monash University
Tom C Kotsimbos (Author) - Monash University
Greg I Snell (Author) - Monash University
Glen P Westall (Author) - Monash University
Publication details: Transplantation, Vol.91(9), pp.1044-1049
Publisher: Lippincott Williams & Wilkins
Date published: 2011
DOI: 10.1097/TP.0b013e318212c7d6
ISSN: 0041-1337; 1534-6080; 0041-1337
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99513883402621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Immunology; Surgery; Transplantation

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