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Published VersionCC BY-NC-ND V4.0, Open Access
Journal article
High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus
iScience, Vol.27(11), pp.1-10
2024
Abstract
Diabetes mellitus significantly increases the risk of severe respiratory virus disease like influenza and COVID-19. Early evidence suggests that this susceptibility to respiratory viral disease is driven by glycemic variability, rather than average blood glucose levels. Here, we use blood samples and constant glucose monitoring (CGM) data obtained from people living with type 1 diabetes (T1D) to determine the effects of glycemic variability on the ex vivo T cell response to influenza virus. We show that high glycemic variability in participants living with T1D is associated with a reduced proportion of CD8+CD107a−IFNγ−MIP1β−TNF+ T cells in response to stimulation with influenza virus and an influenza virus peptide pool. Thus, this study provides evidence that glycemic variability affects the ex vivo T cell response to respiratory viruses. These data suggest that monitoring glycemic variability may have important implications in understanding the antiviral immune response in people with diabetes.
Details
- Title
- High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus
- Authors
- Marcus Z.W. Tong - The University of QueenslandKatina D. Hulme - The University of QueenslandSoi Cheng Law - The University of QueenslandEllesandra Noye - The University of QueenslandEmily S. Dorey - Mater ResearchKeng Yih Chew - The University of QueenslandLouise C. Rowntree - Peter Doherty InstituteCarolien E. van de Sandt - Peter Doherty InstituteKatherine Kedzierska - Peter Doherty InstituteMarco Goeijenbier - Erasmus MCKatharina Ronacher - The University of QueenslandFawaz Alzaid - Université Paris CitéJean-Baptiste Julla - Université Paris CitéJean-Pierre Riveline - Université Paris CitéKatie E. Lineburg - QIMR Berghofer Medical Research InstituteCorey Smith - QIMR Berghofer Medical Research InstituteEmma J. Grant - La Trobe UniversityStephanie Gras - La Trobe UniversityLinda A. Gallo - University of the Sunshine Coast, Queensland, School of Health - BiomedicineHelen L. Barrett - Mater Health ServicesKirsty R. Short (Corresponding Author) - The University of Queensland
- Publication details
- iScience, Vol.27(11), pp.1-10
- Publisher
- Cell Press
- Date published
- 2024
- DOI
- 10.1016/j.isci.2024.111166
- ISSN
- 2589-0042
- Copyright note
- (c) 2024 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- Data Availability
- All data reported in the paper are available from the lead contact upon request. This paper does not report any original code. Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request.
- Grants
- Organisation Unit
- School of Health - Biomedicine
- Language
- English
- Record Identifier
- 991076696702621
- Output Type
- Journal article
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