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Published VersionCC BY V4.0, Open Access
Journal article
High-fidelity replication of thermoplastic microneedles with open microfluidic channels
Microsystems & Nanoengineering, Vol.3(1), pp.1-11
2017
PMID: 31057872
Abstract
Development of microneedles for unskilled and painless collection of blood or drug delivery addresses the quality of healthcare through early intervention at point-of-care. Microneedles with submicron to millimeter features have been fabricated from materials such as metals, silicon, and polymers by subtractive machining or etching. However, to date, large-scale manufacture of hollow microneedles has been limited by the cost and complexity of microfabrication techniques. This paper reports a novel manufacturing method that may overcome the complexity of hollow microneedle fabrication. Prototype microneedles with open microfluidic channels are fabricated by laser stereolithography. Thermoplastic replicas are manufactured from these templates by soft-embossing with high fidelity at submicron resolution. The manufacturing advantages are (a) direct printing from computeraided design (CAD) drawing without the constraints imposed by subtractive machining or etching processes, (b) high-fidelity replication of prototype geometries with multiple reuses of elastomeric molds, (c) shorter manufacturing time compared to three-dimensional stereolithography, and (d) integration of microneedles with open-channel microfluidics. Future work will address development of open-channel microfluidics for drug delivery, fluid sampling and analysis.
Details
- Title
- High-fidelity replication of thermoplastic microneedles with open microfluidic channels
- Authors
- Zahra Faraji Rad (Corresponding Author) - UNSW SydneyRobert E. Nordon - UNSW SydneyCarl J. Anthony - University of BirminghamLynne Bilston - UNSW SydneyPhilip D. Prewett - University of BirminghamJi-Youn Arns - UNSW SydneyChristoph H. Arns - UNSW SydneyLiangchi Zhang - UNSW SydneyGraham J. Davies - UNSW Sydney
- Publication details
- Microsystems & Nanoengineering, Vol.3(1), pp.1-11
- Publisher
- Nature Publishing Group
- Date published
- 2017
- DOI
- 10.1038/micronano.2017.34
- ISSN
- 2055-7434
- PMID
- 31057872
- Copyright note
- This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- Grant note
- NHMRC senior research fellowship; National Health & Medical Research Council (NHMRC) of Australia.
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 991140404402621
- Output Type
- Journal article
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