Journal article
High Diversity of Group A Streptococcal emm Types in an Indian Community: The Need to Tailor Multivalent Vaccines
Clinical Infectious Diseases, Vol.40(1), pp.46-51
2005
Abstract
Background. Concern about the emergence of antibiotic-resistant strains and about morbidity and/or mortality related to rheumatic fever and rheumatic heart disease has been a continuous impetus for the development of a safe, effective vaccine against group A Streptococcus (GAS). To date, >120 GAS M types are known, as identified by serological typing. In general, serum immunoglobulin G directed to the hypervariable NH2 terminal portion of M protein leads to complement fixation and opsonophagocytosis of the homologous streptococcal serotype by polymorphonuclear leukocytes, and the protection is type specific. The sequence variation at the N terminus ultimately affects the binding of opsonic antibodies. Because of hypervariability in these opsonic sequences from different M types, it was relevant to use epitopes derived from these multiple sequences in a "multivalent vaccine" design for evaluation of protection against these M types of GAS. Thus, any attempts to design vaccines for a given community will require information on N terminal-sequence typing and variation. Methods. In the present study, we performed molecular characterization of isolates recovered from patients in northern India-to our knowledge, for the first time-in an attempt to study the circulating M types and their N terminal sequence variability. Results. We report tremendous diversity in GAS strains recovered from symptomatic patients, with implications on the design of appropriate vaccines. Fifty-nine isolates represented 33 different sequence types. Very few novel types and no predominant clones were found. Conclusions. The high diversity of emm types encountered in a single year suggests that any M protein-based multivalent vaccine would have to be specifically tailored for this region.
Details
- Title
- High Diversity of Group A Streptococcal emm Types in an Indian Community: The Need to Tailor Multivalent Vaccines
- Authors
- N Dey (Author) - Departments of Experimental Medicine and Biotechnology, IndiaDavid J McMillan (Author) - Queensland Institute of Medical Research and the Co-operative Research Centre for Vaccine TechnologyP J Yarwood (Author) - Queensland Institute of Medical Research and the Co-operative Research Centre for Vaccine TechnologyR M Joshi (Author) - Government Medical College, IndiaRajesh Kumar (Author) - Post Graduate Institute of Medical Education and Research, IndiaM F Good (Author) - University Medical Centre, NetherlandsK S Sriprakash (Author) - Queensland Institute of Medical Research and the Co-operative Research Centre for Vaccine TechnologyH Vohra (Author) - Departments of Experimental Medicine and Biotechnology, India
- Publication details
- Clinical Infectious Diseases, Vol.40(1), pp.46-51
- Publisher
- Oxford University Press
- Date published
- 2005
- DOI
- 10.1086/426443
- ISSN
- 1058-4838
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99450282602621
- Output Type
- Journal article
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