Journal article
Hepatitis E virus RNA in Australian blood donors: prevalence and risk assessment
Vox Sanguinis, Vol.112(7), pp.614-621
2017
Abstract
BACKGROUND AND OBJECTIVES: Hepatitis E virus (HEV) is a known transfusion-transmissible agent. HEV infection has increased in prevalence in many developed nations with RNA detection in donors as high as 1 in 600. A high proportion of HEV infections are asymptomatic and therefore not interdicted by donor exclusion criteria. To manage the HEV transfusion-transmission (TT) risk some developed nations have implemented HEV RNA screening. In Australia, HEV is rarely notified; although locally acquired infections have been reported, and the burden of disease is unknown. The purpose of this study was to determine the frequency of HEV infection in Australian donors and associated TT risk. MATERIALS AND METHODS: Plasma samples (n = 74 131) were collected from whole blood donors during 2016 and screened for HEV RNA by transcription-mediated amplification (TMA) in pools of six. Individual TMA reactive samples were confirmed by RT-PCR and, if positive, viral load determined. Prevalence data from the study were used to model the HEV-TT risk. RESULTS: One sample in 74 131 (95% CI: 1 in 1 481 781 to 1 in 15 031) was confirmed positive for HEV RNA, with an estimated viral load of 180 IU/ml, which is below that typically associated with TT. Using a transmission-risk model, we estimated the risk of an adverse outcome associated with TT-HEV of approximately 1 in 3.5 million components transfused. CONCLUSION: Hepatitis E virus viremia is rare in Australia and lower than the published RNA prevalence estimates of other developed countries. The risk of TT-HEV adverse outcomes is negligible, and HEV RNA donor screening is not currently indicated.
Details
- Title
- Hepatitis E virus RNA in Australian blood donors: prevalence and risk assessment
- Authors
- V C Hoad (Author)C R Seed (Author)J J Fryk (Author)R Harley (Author)R L P Flower (Author)B M Hogema (Author)P Kiely (Author)Helen M Faddy (Corresponding Author) - Australian Red Cross Blood Service
- Publication details
- Vox Sanguinis, Vol.112(7), pp.614-621
- Publisher
- Wiley-Blackwell Publishing Ltd.
- Date published
- 2017
- DOI
- 10.1111/vox.12559
- ISSN
- 0042-9007; 1423-0410; 0042-9007
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99451412002621
- Output Type
- Journal article
Metrics
49 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- International collaboration
- Web Of Science research areas
- Hematology
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites